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Highly efficient and catalyst-free synthesis of unsymmetrical thioureas under solvent-free conditions

Ziyaei Halimehjani, A ; Sharif University of Technology | 2009

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  1. Type of Document: Article
  2. DOI: 10.1016/j.tetlet.2008.10.063
  3. Publisher: 2009
  4. Abstract:
  5. A highly efficient and simple synthesis of unsymmetrical thioureas is reported based on the reaction of readily synthesized dithiocarbamates with amines, without using any catalyst under solvent-free conditions. The short reaction time, high yields, and solvent-free conditions are advantages of this method. We did not observe the formation of any symmetric disubstituted thiourea, under these reaction conditions. © 2008 Elsevier Ltd. All rights reserved
  6. Keywords:
  7. Amine ; Dithiocarbamic acid derivative ; Thiourea derivative ; Article ; Catalysis ; Chemical reaction ; Chemical structure ; Column chromatography
  8. Source: Tetrahedron Letters ; Volume 50, Issue 1 , 2009 , Pages 32-34 ; 00404039 (ISSN)
  9. URL: https://www.sciencedirect.com/science/article/pii/S0040403908019564