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The ITO-capped WO3 nanowires biosensor based on field-effect transistor in label-free protein sensing

Shariati, M ; Sharif University of Technology | 2017

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  1. Type of Document: Article
  2. DOI: 10.1007/s00339-017-0994-2
  3. Publisher: Springer Verlag , 2017
  4. Abstract:
  5. The fabrication of ITO-capped WO3 nanowires associated with their bio-sensing properties in field-effect transistor diagnostics basis as a biosensor has been reported. The bio-sensing property for manipulated nanowires elucidated that the grown nanostructures were very sensitive to protein. The ITO-capped WO3 nanowires biosensor showed an intensive bio-sensing activity against reliable protein. Polylysine strongly charged bio-molecule was applied as model system to demonstrate the implementation of materialized biosensor. The employed sensing mechanism was ‘label-free’ and depended on bio-molecule’s intrinsic charge. For nanowires synthesis, the vapor–liquid–solid mechanism was used. Nanowires were beyond a few hundred nanometers in lengths and around 15–20 nm in diameter, while the globe cap’s size on the nanowires was around 15–25 nm. The indium tin oxide (ITO) played as catalyst in nanofabrication for WO3 nanowires growth and had outstanding role in bio-sensing especially for bio-molecule adherence. In applied electric field presence, the fabricated device showed the great potential to enhance medical diagnostics. © 2017, Springer-Verlag Berlin Heidelberg
  6. Keywords:
  7. Biosensors ; Diagnosis ; Electric fields ; Molecules ; Nanowires ; Proteins ; Tin oxides ; Fabricated device ; Indium tin oxide ; Label free ; Medical diagnostics ; Model system ; Polylysine ; Protein sensing ; Sensing mechanism ; Field effect transistors
  8. Source: Applied Physics A: Materials Science and Processing ; Volume 123, Issue 5 , 2017 ; 09478396 (ISSN)
  9. URL: https://link.springer.com/article/10.1007%2Fs00339-017-0994-2