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Smart micro/nano-robotic systems for gene delivery

Pedram, A ; Sharif University of Technology | 2017

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  1. Type of Document: Article
  2. DOI: 10.2174/1566523217666170511111000
  3. Publisher: Bentham Science Publishers B.V , 2017
  4. Abstract:
  5. Background: Small scale robotics have attracted growing attention for the prospect of targeting and accessing cell-sized sites, necessary for high precision biomedical applications and drug/gene delivery. The loss of controlled gene therapy, inducing systemic side effects and reduced therapeutic efficiency, can be settled utilizing these intelligent carriers. Methods: Newly proposed solutions for the main challenges of control, power supplying, gene release and final carrier extraction/degradation have shifted these smart miniature robots to the point of being employed for practical applications of transferring oligonucleotides (pDNA, siRNA, mRNA, etc.) in near future. Conclusion: In this paper, different scenarios and their endeavors to address the vital working demands and steps, in particular, carrier attachment and release, cell internalization, manipulation concerns as well as actuation systems are discussed.This review highlights some promising experimental results showing controlled gene release of robotic systems in comparison with current non-specific gene delivery methods. © 2017 Bentham Science Publishers
  6. Keywords:
  7. Chemotaxis ; Gene delivery ; Gene release ; Hybrid systems ; Micro/nano-robotics ; MRI actuation
  8. Source: Current Gene Therapy ; Volume 17, Issue 2 , 2017 , Pages 73-79 ; 15665232 (ISSN)
  9. URL: http://www.eurekaselect.com/152357/article