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A spatially-variant deconvolution method based on total variation for optical coherence tomography images

Almasganj, M ; Sharif University of Technology

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  1. Type of Document: Article
  2. DOI: 10.1117/12.2255557
  3. Abstract:
  4. Optical Coherence Tomography (OCT) has a great potential to elicit clinically useful information from tissues due to its high axial and transversal resolution. In practice, an OCT setup cannot reach to its theoretical resolution due to imperfections of its components, which make its images blurry. The blurriness is different alongside regions of image; thus, they cannot be modeled by a unique point spread function (PSF). In this paper, we investigate the use of solid phantoms to estimate the PSF of each sub-region of imaging system. We then utilize Lucy-Richardson, Hybr and total variation (TV) based iterative deconvolution methods for mitigating occurred spatially variant blurriness. It is shown that the TV based method will suppress the so-called speckle noise in OCT images better than the two other approaches. The performance of proposed algorithm is tested on various samples, including several skin tissues besides the test image blurred with synthetic PSF-map, demonstrating qualitatively and quantitatively the advantage of TV based deconvolution method using spatially-variant PSF for enhancing image quality. © 2017 SPIE
  5. Keywords:
  6. Optical coherence tomography ; Deconvolution ; Histology ; Iterative methods ; Medical applications ; Molecular imaging ; Optical tomography ; Optical transfer function ; Tissue ; Tomography ; Deconvolution method ; Iterative deconvolution methods ; Lucy-richardson ; Solid phantoms ; Speckle noise ; Total variation ; Transversal resolution ; Unique points ; Medical imaging
  7. Source: Progress in Biomedical Optics and Imaging - Proceedings of SPIE, 12 February 2017 through 14 February 2017 ; Volume 10137 , 2017 ; 16057422 (ISSN) ; 9781510607194 (ISBN)
  8. URL: https://www.spiedigitallibrary.org/conference-proceedings-of-spie/10137/1013725/A-spatially-variant-deconvolution-method-based-on-total-variation-for/10.1117/12.2255557.short?SSO=1