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Evaluating the Effect of Antiviral Agents on Influenza H1N1 Virus

Haghayegh Khorasani, Sara | 2019

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  1. Type of Document: M.Sc. Thesis
  2. Language: Farsi
  3. Document No: 51662 (06)
  4. University: Sharif University of Technology
  5. Department: Chemical and Petroleum Engineering
  6. Advisor(s): Roosta Azad, Reza; Dorostkar, Ruhollah
  7. Abstract:
  8. With the epidemic of viral diseases in humans and animals, and their potential to cause irreparable economic damages, due to their recent noticeable changes in their structures followed by becoming antibiotic resistance, many researchers nowadays are focusing on the new antiviral Agents with least side effects. Influenza A virus is a common seasonal virus which can lead to sever infections. This type of influenza has the ability to transmit between humans and animals, and also by antigenic shifts can transform to new type of influenza which can cause a global disaster. While classical antiviral drugs are still in use for influenza patients, new influenza A subtypes become resistant to these common prescribing drugs. Moreover, the side effects of these drugs can have more devastating effects than the infection itself. Hence, introducing new antiviral agents with effective functions and the least side effects could change worldwide views toward this virus. In this study, a natural indigenous Iranian plant, Peganum Harmala and its derivatives, such as extractions of various parts of this plant and its smoke, was used in order to investigate their antiviral properties against influenza H1N1 virus in vitro. As its smoke was firstly used against Influenza virus, its organic extract was chromatographed, and the main compositions of it, which are responsible for its toxicity and anti-viral properties, were determined. The aqueous extracts of P.harmala seeds, seeds powder, whole plant powder and its smoke, with concentrations of 103,102,103, 33×103 µg/ml respectively, and P.harmala smoke alone, with the concentration of 20cm3 at the contact time of 2 minutes, could inhibit the influenza H1N1 virus significiantly. The indicated results from HA tests showed a significant decrease in the virus load, and P.harmala once again proved to be a great natural antiviral agent against this virus
  9. Keywords:
  10. Influenza Virus ; Antiviral Agents ; Medical Plants ; Peganum Harmala

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