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Modified Lignin Natural Polymer and Graphene Oxide Aerogels and Valuation of their Performance in Sample Preparation

Taherzadeh, Mehrnoush | 2019

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  1. Type of Document: M.Sc. Thesis
  2. Language: Farsi
  3. Document No: 52310 (03)
  4. University: Sharif University of Technology
  5. Department: Chemistry
  6. Advisor(s): Bagheri, Habib
  7. Abstract:
  8. A green aerogel was prepared by synthesizing amine-modified lignin from sugarcane bagasse and further modification by CS2 and subsequent freeze drying. This aerogel was implemented as an extractive phase in a home-made online micro solid phase extraction-high performance liquid chromatography (μSPE-HPLC) setup for analyzing cardiovascular drugs (valsartan and losartan) in urine samples. To study the effect of functionalization, bare or functionalized lignin powders were mixed with graphene oxide (GO) at different ratios while functionalized lignin showed the highest efficiency. The prepared aerogel was analyzed using CHNS elemental analysis, and FT-IR spectrometry. Effects of influencing parameters on the extraction efficiency were optimized. Under the optimized conditions, figures of merit including limit of detection of 6 and 8 〖μg.L〗^(-1), limits of quantification 20, 27〖μg.L〗^(-1) and linear dynamic ranges of 20-2000 and 27-2000〖μg.L〗^(-1) with relative standard deviations of 4 and 3% were obtained for valsartan and losartan, respectively. The whole method was implemented for analysis of urine samples. Acceptable relative recoveries (109 and 95% for valsartan and losartan) revealed the capacity of the method for analysis of drugs in complex urine samples
  9. Keywords:
  10. Natural Polymer ; Lignin ; Functionalized Lignin ; Micro-Solid Phase Extraction ; High Performance Liquid Chromatography ; Cardiovascular Drugs

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