Loading...

Mathematical Modeling and Simulation of Hyperbaric Oxygen Therapy in Tumor Growth Process

Baghani, Elham | 2019

616 Viewed
  1. Type of Document: M.Sc. Thesis
  2. Language: Farsi
  3. Document No: 52653 (06)
  4. University: Sharif University of Technology
  5. Department: Chemical and Petroleum Engineering
  6. Advisor(s): Abdekhodaei, Mohammad Jafar; Saadatmand, Maryam
  7. Abstract:
  8. Today cancer is one of the leading causes of death worldwide. It is caused by some cells that they gather together in part of the body and they have an abnormal and very high proliferation rate. Investigations on tumors have shown that when tumor volume increases, oxygen concentration in some regions of tumors decreases and this hypoxic condition leads to some cancer hallmarks, e.g. angiogenesis, deregulation of apoptosis, and shift in cell energy sources. So treatment strategies that can increase tissue oxygenation are good choices for cancers. Hyperbaric oxygen therapy (HBOT) which is used to treat diabetic ulcers and carbon monoxide poisoning, have been used experimentally for cancer and have shown good results. Beside experimental trials, mathematical modeling of biological processes is a good way to understand how they work. The aim of this study is to simulate Hbot effects on tumor growth process. For this purpose, first some equations for tumor cells and oxygen have been considered. Then angiogenesis and Reactive Oxygen Species (ROS) roles in tumor growth have been modeled. Finally after completion of these equations, Hbot effects on this system have been investigated. Results show that Hbot can decrease angiogenesis and increase ROS concentrations above the toxicity threshold and kill cancerous cells. So Hbot can decrease tumor growth rate
  9. Keywords:
  10. Cancer ; Oxygen ; Tumor Growth ; Mathematical Modeling ; Hyperbaric Oxygen Therapy ; Angiogenesis ; Reactive Oxygen Species (ROS)

 Digital Object List

 Bookmark

No TOC