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Range Verification and Dose Evaluation in Proton Therapy by Using Monte Carlo Method

Rabiee, Zahra | 2020

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  1. Type of Document: M.Sc. Thesis
  2. Language: Farsi
  3. Document No: 53389 (46)
  4. University: Sharif University of Technology
  5. Department: Energy Engineering
  6. Advisor(s): Vosoughi, Naser
  7. Abstract:
  8. In this study, the emission and detection of secondary particles such as gamma and neutron along the beam path was investigated to evaluate proton range during treatment. Simulations and detections were performed by Geant4 toolkit that was developed base on Monte Carlo method. First, a mono-energetic proton beams irradiated a homogeneous water phantom. Then the factors influencing the accuracy of beam range estimation have been investigated and finally proton beam range was evaluated by simulation the human eye phantom. According to the results, the accuracy of range verification by prompt gamma is very high, about 1 mm. In phantoms with more oxygen in their composition, the percentage of relative error is more. Also, the accuracy of the range verification increases with increasing the energy of the incident proton beam. In different characteristic prompt gamma, the accuracy of the Bragg peak position estimation decreases with increases the energy corresponding to the maximum point of the cross-section curve that produce that special characteristic prompt gamma. Finally, the presence of heterogeneity within the phantom has the same effect on the shift of the Bragg peak and the secondary particle yield in depth. Investigating the feasibility of evaluating the proton beam range by secondary neutrons and analyzing the behavior of curves based on the cross-section of different reactions are among the innovations of this study
  9. Keywords:
  10. Monte Carlo Method ; Prompt Gamma Neutron Activation Analysis (PGNAA) ; GEANT4 Toolkit ; Neatrons ; Range Verification ; Proton Therapy

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