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Synthesis of highly functionalized quinazoline-2,4(1H,3H)-diones from isocyanides, aniline and isocyanate via Cu-catalyzed intermolecular C-H activation reactions

Nematpour, M ; Sharif University of Technology | 2020

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  1. Type of Document: Article
  2. DOI: 10.2174/1570178616666190905142545
  3. Publisher: Bentham Science Publishers , 2020
  4. Abstract:
  5. A simple and appropriate procedure for the synthesis of quinazoline-2,4(1H,3H)-dione derivatives from isocyanides, aniline and isocyanate via the Cu-catalyzed intramolecular C-H activation reaction is reported. The advantages of this method are one-pot conditions, accessible starting materials-catalyst, high yield of products, and short reaction times. The structures are confirmed spectroscopically (1H-and13C-NMR, IR and EI-MS) and by elemental analyses. © 2020 Bentham Science Publishers
  6. Keywords:
  7. 4(1H, 3H)-diones ; Aniline ; C-H activation ; Cu-catalyzed ; Isocyanate ; Isocyanides ; Quinazoline-2 ; Quinazoline-2,4(1H,3H)-dione
  8. Source: Letters in Organic Chemistry ; Volume 17, Issue 11 , 2020 , Pages 832-836
  9. URL: https://www.eurekaselect.com/174709/article