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- Type of Document: M.Sc. Thesis
- Language: Farsi
- Document No: 53711 (08)
- University: Sharif University of Technology
- Department: Mechanical Engineering
- Advisor(s): Taghipoor, Mojtaba; Hosseini, Vahid
- Abstract:
- Solid-state micro/nanopores have been widely used as a sensor for detection, counting, sizing, and measuring the surface charge of micro (such as cells and bacteria) and nanoparticles (such as viruses, exosomes and DNA) in the last decades and there have been numerous studies regarding the fabrication of single micro/nanopores. Most of the conventional methods require the use of advanced devices such as electron and ion microscopes to fabricate these micro/nanopores. Therefore, the final cost of them is generally high. Given that, in this study, a novel and affordable method is developed for the fabrication of single micro/nanopores of different sizes. This method is based on molding the collision area of two superimposed and crossing objects with sharp edges. For this purpose, a system was designed and manufactured for aligning and molding these two objects. Then a setup was designed and fabricated for electrochemical measurement of the fabricated micro/nanopore and used for the size estimation of the nanopores that could not be seen in light microscopy. According to this estimation, the smallest fabricated pore had a diameter of 400nm. In the last step, a novel method was developed for size tuning of the micro/nanopore for achieving better resolution in micro/nanoparticle detection. This method is based on using under tension or compression layers in a bended plate. In this way, if the pore is placed on a compression layer, its size will reduce, and if it is placed on a stretched layer, its size will be increase. The results of electrochemical measurement of micro/nanopores showed that by using this method, the pore can be reduced to the limit of clogging, and on the other hand, by applying tensile stress, its electrical conductivity can be increased several times. Due to its simple and low-cost fabrication, this method can be a suitable alternative to conventional micro/nanopore fabrication methods, which often require expensive equipment
- Keywords:
- Micropore Fabrication ; Electrochemical Measurement ; Micro/Nanoparticle Sensor Detection ; Micro/Nanopore Size Tuning ; Microparticles ; Nanometric Particle Size
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