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Opposite trends of GAS6 and GAS6-AS expressions in breast cancer tissues

Lavasani, A ; Sharif University of Technology | 2021

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  1. Type of Document: Article
  2. DOI: 10.1016/j.yexmp.2020.104600
  3. Publisher: Academic Press Inc , 2021
  4. Abstract:
  5. Growth arrest-specific gene 6 (GAS6) is a growth factor-like cytokine whose function is related with vitamin K. This protein interacts with receptor tyrosine kinase proteins such as Tyro3, Axl, and TAM Receptor family, therefore affecting the tumorigenic processes via different mechanisms. GAS6-antisense 1 (GAS6-AS1) is a long non-coding RNAs (lncRNAs) that is transcribed from a genomic regions nearby GAS6. This lncRNA is also implicated in the pathobiology of cancer. We intended to judge the role of GAS6 and GAS6-AS1 in the pathogenesis of breast cancer through appraisal of their expression levels in breast cancer tissues and their paired neighboring non-cancerous samples. Expression of GAS6 was up-regulated in breast cancer tissues compared with neighboring tissues (Ratio of Mean Expressions = 2.18, P value = 4.98E-02). On the other hand, expression of GAS6-AS1 was down-regulated in breast tumor tissues compared with controls (Ratio of Mean Expressions = 0.37, P value = 4.26E-03). There were substantial correlations between expression levels GAS6 and GAS6-AS1 in non-cancerous tissues (r = 0.74, P value = 1.47e-13) and cancer tissues (r = 0.85, P value = 2.28e-20). Expression of GAS6-AS was associated with progesterone receptor status (P value = 1.36E-02). However, expressions of this gene and the sense transcript were not linked with any other clinical or demographic variable. Taken together, GAS6 and GAS6-AS1 might partake in the development of breast cancer. © 2020 Elsevier Inc
  6. Keywords:
  7. Estrogen ; Growth arrest specific protein 6 ; Oral contraceptive agent ; Epidermal growth factor receptor 2 ; ERBB2 protein, human ; Estrogen receptor ; Growth arrest-specific protein 6 ; Long untranslated RNA ; Progesterone receptor ; Signal peptide ; Tumor marker ; Abortion ; Adult ; Aged ; Breast cancer ; Breast feeding ; Breast tissue ; Cancer grading ; Cancer patient ; Cancer size ; Cancer staging ; Cancer tissue ; Carcinogenesis ; Controlled study ; Correlation analysis ; Diagnostic test accuracy study ; Down regulation ; Estrogen deficiency ; GAS6 AS gene ; GAS6 gene ; Gene ; Gene expression ; Gene expression level ; Gene expression regulation ; Gene function ; Genetic transcription ; Histopathology ; Hormone substitution ; Human ; Human tissue ; Machine learning ; Major clinical study ; Menarche ; Menopause ; Mitosis ; Oral contraceptive use ; Polymerase chain reaction ; Sensitivity and specificity ; Trend study ; Upregulation ; Breast tumor ; Case control study ; Follow up ; Genetics ; Metabolism ; Middle aged ; Pathology ; Receiver operating characteristic ; Adolescent ; Biomarkers, Tumor ; Breast Neoplasms ; Case-Control Studies ; Child ; Female ; Follow-Up Studies ; Gene Expression Regulation, Neoplastic ; Humans ; Intercellular Signaling Peptides and Proteins ; Middle Aged ; Prognosis ; Receptor, ErbB-2 ; Receptors, Estrogen ; Receptors, Progesterone ; RNA, Long Noncoding ; ROC Curve
  8. Source: Experimental and Molecular Pathology ; Volume 118 , 2021 ; 00144800 (ISSN)
  9. URL: https://www.sciencedirect.com/science/article/abs/pii/S0014480020308777