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Design and Simulation of Bioimpedance Chip for Monitoring Heart Failure

Rezapour, Mojtaba | 2021

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  1. Type of Document: M.Sc. Thesis
  2. Language: Farsi
  3. Document No: 54678 (05)
  4. University: Sharif University of Technology
  5. Department: Electrical Engineering
  6. Advisor(s): Sharifkhani, Mohammad
  7. Abstract:
  8. Cardiovascular disease is one of the leading causes of death and mortality. among these diseases, heart muscle inability, especially acute decompensated heart failure is very common. There are several methods to diagnose and monitor this disease, but a method that is accurate, non-invasive, portable and easy to access and easy to measure without multiple visits to the clinic; Priority for use. Early detection and continuous monitoring of fluid status by measuring the bio-impedance (Bio-Z) measurement of thoracic magnitude or phase is critical in reducing the mortality of chronic heart failure (CHF) patients. In this dissertation, for monitoring chronic heart failure, bio-impedance chips with frequency spectroscopy methods up to a maximum frequency of 1 MHz are proposed. The two most important blocks of this chip include current driver with wide bandwidth, high output impedance (accuracy above 0.1%), sub 1.5° phase delay, below 0.1% total harmonic distortion, effective output common mode signal reduction, low power consumption up to 3.4 mW and IA with wideband, low power consumption 300 µW, rail-to-rail differentially electrode offset cancellation, 20 mΩ/√Hz resolution and sub 4° phase delay specifications in 0.18 µm–1.8 V technology is designed and simulated. Due to its high accuracy, this chip can be used in other important applications such as detecting cancer cells in its early stages
  9. Keywords:
  10. Heart Diseases ; Instrumentation Amplifier (IA) ; Ultra Wideband ; Congestive Heart Failure (CHF) ; Bioimpedance Spectroscopy ; Thoracic Impedance Variance (TIV) ; Low Phase Error ; Current Driver (CD) ; Current Feedback Instrumentation Amplifier (CFIA)

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