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KF/Al2O3-mediated Michael addition of thiols to electron-deficient olefins

Moghaddam, F. M ; Sharif University of Technology | 2005

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  1. Type of Document: Article
  2. DOI: 10.1080/00397910500189783
  3. Publisher: 2005
  4. Abstract:
  5. Potassium fluoride supported on alumina efficiently catalyzes Michael addition of aromatic and aliphatic thiols to a variety of conjugated alkenes such as α,β-unsaturated carbonyl compounds, carboxylic esters, amides, nitriles and chalcones. The Michael adducts are produced in good to excellent yields and relatively in short times. The catalyst can be recycled for subsequent reactions without any appreciable loss of efficiency. Copyright © Taylor & Francis, Inc
  6. Keywords:
  7. Aliphatic compound ; Alkene ; Aluminum oxide ; Amide ; Aromatic compound ; Carbonyl derivative ; Chalcone ; Ester ; Nitrile ; Potassium fluoride ; Thiol derivative ; Catalysis ; Chemical reaction ; Electron ; Michael addition ; Reaction analysis ; Synthesis
  8. Source: Synthetic Communications ; Volume 35, Issue 18 , 2005 , Pages 2427-2433 ; 00397911 (ISSN)
  9. URL: https://www.tandfonline.com/doi/abs/10.1080/00397910500189783