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A novel procedure for conversion of epoxides to α -hydroxyphosphonates with a trialkylphosphite mediated by LiClO4

Azizi, N ; Sharif University of Technology | 2003

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  1. Type of Document: Article
  2. DOI: 10.1016/j.tetlet.2003.09.002
  3. Publisher: Elsevier Ltd , 2003
  4. Abstract:
  5. A new method has been developed for the direct conversion of epoxides to α-hydroxyphosphonates by the reaction of a trialkylphosphite with the epoxide in 5 M lithium perchlorate in diethyl ether (LPDE). The reaction is highly regioselective and efficient with excellent yields under mild and neutral conditions. © 2003 Published by Elsevier Ltd
  6. Keywords:
  7. Epoxide ; Lithium perchlorate ; Trialkylphosphite ; α-hydroxyphosphonates
  8. Source: Tetrahedron Letters ; Volume 44, Issue 43 , 2003 , Pages 7933-7935 ; 00404039 (ISSN)
  9. URL: https://www.sciencedirect.com/science/article/pii/S0040403903020690?via%3Dihub