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Drug release mechanisms from composite matrices I. Theoretical issues

Abdekhodaie, M. J ; Sharif University of Technology | 2002

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  1. Type of Document: Article
  2. Publisher: Sharif University of Technology , 2002
  3. Abstract:
  4. In this paper, composites containing hydrophilic particles uniformly dispersed within a hydrophobic network have been studied. Theoretical issues governing the release characteristics have been defined. When the hydrophilic content is below the percolation threshold, either equilibrium swelling or osmotic rupturing would occur. Theoretical criteria to determine whether equilibrium swelling or osmotic rupturing would occur are defined and a model for predicting the extent of equilibrium swelling in the presence of mechanical constraint is offered. Different drug release mechanisms can be achieved by choosing different materials and various formulation factors
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  7. Source: Scientia Iranica ; Volume 9, Issue 1 , 2002 , Pages 1-8 ; 10263098 (ISSN)
  8. URL: http://scientiairanica.sharif.edu/article_2718.html