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Mass transfer analysis of penicillin extraction

Kheirolomoom, A ; Sharif University of Technology | 2001

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  1. Type of Document: Article
  2. Publisher: Sharif University of Technology , 2001
  3. Abstract:
  4. In this paper, recovery of penicillin G from mycel-containing fermentation broth through physical extraction is investigated. The values of degree of extraction are evaluated as a function of media pH, partition coefficient between aqueous and organic phases for undissociated acid and the pKa of penicillin. The pH variations were measured during extraction operation and the optimum pH value for penicillin G recovery considering its decomposition was obtained. The mass transfer analysis of the extraction system was carried out using two-resistance mass transfer theory. The overall as well as aqueous and organic phase mass transfer coefficients were determined. The investigated mass transfer resistances for both phases are in the same order of magnitude, demonstrating that the mass transfer resistances for both phases have to be considered in equipment design and operation of penicillin G extraction systems
  5. Keywords:
  7. Source: Scientia Iranica ; Volume 8, Issue 3 , 2001 , Pages 179-184 ; 10263098 (ISSN)
  8. URL: http://scientiairanica.sharif.edu/article_2746.html