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- Type of Document: M.Sc. Thesis
- Language: English
- Document No: 55618 (58)
- University: Sharif University of Technology, International Campus, Kish Island
- Department: Mechanical Engineering
- Advisor(s): Ahmadian, Mohammad Taghi
- Abstract:
- The injection process on cell is a very accurate and sensitive operation. This method is used for several new invented approaches such as tracytoplasmic Cell Injection or drug delivery. Controlling the injection force in micro scale is one of the problems of mentioned operations. Current huge and expensive laboratorial devices are helping the operators to do injection operation with :nore success. In this study a simple and novel microelectromechanical (MEMS) mechanism for doing injection process automatically on the biological cells is proposed. In order to controlling this device properly, we should model and simulate the operation condition from initial position to final condition. This is performed by using axisymmetric finite element method to model the cell and deriving the deformation of the particles in a frictionless tapered micropipette when needle is exerted by force. The elements used in our method are considered as viscoelastic elements and this property is implemented in the FEM formulation. Finally the required force for penetration and stresses at this point are evaluated. The deformation of the cell under external force in the process of injection is also demonstrated
- Keywords:
- Microelectromechanical Systems (MEMS) ; Viscoelastic Cell Model ; Intracytoplasmic Cell Injection ; Cell Injeetion ; Axisymmetric Finite Element Method ; Cell Deformation ; Manipulation System
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