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Automatic detection of respiratory events during sleep from Polysomnography data using Layered Hidden Markov Model

Sadoughi, A ; Sharif University of Technology | 2022

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  1. Type of Document: Article
  2. DOI: 10.1088/1361-6579/ac45e1
  3. Publisher: IOP Publishing Ltd , 2022
  4. Abstract:
  5. Objective. Sleep apnea is a serious respiratory disorder, which is associated with increased risk factors for cardiovascular disease. Many studies in recent years have been focused on automatic detection of sleep apnea from polysomnography (PSG) recordings, however, detection of subtle respiratory events named Respiratory Event Related Arousals (RERAs) that do not meet the criteria for apnea or hypopnea is still challenging. The objective of this study was to develop automatic detection of sleep apnea based on Hidden Markov Models (HMMs) which are probabilistic models with the ability to learn different dynamics of the real time-series such as clinical recordings. Approach. In this study, a hierarchy of HMMs named Layered HMM was presented to detect respiratory events from PSG recordings. The recordings of 210 PSGs from Massachusetts General Hospital's database were used for this study. To develop detection algorithms, extracted feature signals from airflow, movements over the chest and abdomen, and oxygen saturation in blood (SaO2) were chosen as observations. The respiratory disturbance index (RDI) was estimated as the number of apneas, hypopneas, and RERAs per hour of sleep. Main results. The best F1 score of the event by event detection algorithm was between 0.22 ± 0.16 and 0.70 ± 0.08 for different groups of sleep apnea severity. There was a strong correlation between the estimated and the PSG-derived RDI (R 2 = 0.91, p < 0.0001). The best recall of RERA detection was achieved 0.45 ± 0.27. Significance. The results showed that the layered structure can improve the performance of the detection of respiratory events during sleep. © 2022 Institute of Physics and Engineering in Medicine
  6. Keywords:
  7. Event detection ; Hidden Markov Model ; Respiratory Event Related Arousals ; Signal detection ; Sleep research ; Automatic Detection ; Disturbance index ; Events detection ; Hidden-Markov models ; Layered hidden markov models ; Respiratory disturbance index ; Respiratory disturbances ; Respiratory event related arousal ; Sleep apnea ; Hidden Markov models ; Human ; Sleep ; Sleep disordered breathing ; Arousal ; Humans ; Polysomnography ; Sleep Apnea Syndromes ; Sleep Apnea, Obstructive
  8. Source: Physiological Measurement ; Volume 43, Issue 1 , 2022 ; 09673334 (ISSN)
  9. URL: https://iopscience.iop.org/article/10.1088/1361-6579/ac45e1