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Synthesis and characterization of 1-amidino-O-alkylureas metal complexes as α- glucosidase Inhibitors: Structure-activity relationship, molecular docking, and kinetic studies

Moghaddam, F. M ; Sharif University of Technology | 2022

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  1. Type of Document: Article
  2. DOI: 10.1016/j.molstruc.2021.131726
  3. Publisher: Elsevier B.V , 2022
  4. Abstract:
  5. In the present study, metal complexes of 1-amidino-O-alkylureas were designed, synthesized and characterized by elemental analyses, FT-IR spectra, XRD, Mass analyses and scanning electron microscopy (SEM). All synthesized complexes were screen as α-Glucosidase inhibitors. According to the in vitro results, the Cu (II) complexes showed superior potency compared to other tested metal complexes. Particularly, [Cu(L-Me)2](Cl)2 (1b) showed the strongest inhibition against α-Glucosidase with an IC50 value of 2.75 ± 0.3 µM which was comparable to that of acarbose (IC50 = 750 µM). These findings are supported by the ligands and enzyme interactions through molecular docking. © 2021 Elsevier B.V
  6. Keywords:
  7. Metal complex ; Metformin ; α-Glucosidase ; Chlorine compounds ; Copper compounds ; Metals ; Molecular modeling ; Scanning electron microscopy ; Synthesis (chemical) ; Antidiabetic effects ; Glucosidase ; Glucosidase inhibitors ; Homology modeling ; Metformins ; Molecular docking ; Structure-activity relationships ; Synthesis and characterizations ; Synthesised ; Α-glucosidase ; Metal complexes
  8. Source: Journal of Molecular Structure ; Volume 1250 , 2022 ; 00222860 (ISSN)
  9. URL: https://www.sciencedirect.com/science/article/abs/pii/S0022286021018524