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Facile one-pot, multi-component reaction to synthesize spirooxindole-annulated thiopyran derivatives under environmentally benevolent conditions

Matloubi Moghaddam, F ; Sharif University of Technology | 2022

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  1. Type of Document: Article
  2. DOI: 10.1016/j.heliyon.2022.e10666
  3. Publisher: Elsevier Ltd , 2022
  4. Abstract:
  5. An efficient and facile one-pot, five-component reaction for the synthesis of 2,6-diamino-1-alkyl-2-oxospiro[indoline-3,4′-thiopyran]-3,5-dicarbonitrile derivatives has been reported by a reaction between primary amines, carbon disulfide, malononitrile, and isatin derivatives. The major advantages of this procedure are high yields of products in relatively short reaction time, scalability, mild conditions, multi-component synthetic procedure, low catalyst loading, no column separation and simple reaction work-up. As a consequence, this synthetic procedure provided an efficient access to spirooxindole-annulated thiopyran derivatives. © 2022
  6. Keywords:
  7. 2,6-Diamino-1-alkyl-2-oxospiro[indoline-3,4′-thiopyran]-3,5-dicarbonitrile ; Dithiocarbamate ; Green chemistry ; Multi-component reaction ; Spirooxindole-annulated thiopyran derivatives
  8. Source: Heliyon ; Volume 8, Issue 9 , Volume 8, Issue 9 , 2022 ; 24058440 (ISSN)
  9. URL: https://www.sciencedirect.com/science/article/pii/S2405844022019545?dgcid=rss_sd_all