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Salience memories formed by value, novelty and aversiveness jointly shape object responses in the prefrontal cortex and basal ganglia

Ghazizadeh, A ; Sharif University of Technology | 2022

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  1. Type of Document: Article
  2. DOI: 10.1038/s41467-022-33514-3
  3. Publisher: Nature Research , 2022
  4. Abstract:
  5. Ecological fitness depends on maintaining object histories to guide future interactions. Recent evidence shows that value memory changes passive visual responses to objects in ventrolateral prefrontal cortex (vlPFC) and substantia nigra reticulata (SNr). However, it is not known whether this effect is limited to reward history and if not how cross-domain representations are organized within the same or different neural populations in this corticobasal circuitry. To address this issue, visual responses of the same neurons across appetitive, aversive and novelty domains were recorded in vlPFC and SNr. Results showed that changes in visual responses across domains happened in the same rather than separate populations and were related to salience rather than valence of objects. Furthermore, while SNr preferentially encoded outcome related salience memory, vlPFC encoded salience memory across all domains in a correlated fashion, consistent with its role as an information hub to guide behavior. © 2022, The Author(s)
  6. Keywords:
  7. Fitness ; Memory ; Visual cue ; Basal ganglion ; Nerve cell ; Substantia nigra pars reticulata ; Ventrolateral prefrontal cortex ; Brain cortex ; Physiology ; Basal Ganglia ; Cerebral Cortex ; Neurons ; Prefrontal Cortex ; Reward
  8. Source: Nature Communications ; Volume 13, Issue 1 , 2022 ; 20411723 (ISSN)
  9. URL: https://www.nature.com/articles/s41467-022-33514-3