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Determination of Correlation between Phase Amplitude Coupling and Surprise in Brain

Heidari Beni, Mohammad Hossein | 2022

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  1. Type of Document: M.Sc. Thesis
  2. Language: Farsi
  3. Document No: 55719 (05)
  4. University: Sharif University of Technology
  5. Department: Electrical Engineering
  6. Advisor(s): Karblaei Aghajan, Hamid
  7. Abstract:
  8. The human brain needs to create a model of data surrounding it continuously. To do so, handling the dynamics of information through communication between the brain regions is a critical step. Having a model of this procedure in the brain not only provides a clear explanation of how cognition occurs in the brain, but also enables us to have a better view of the cognition impairments in the brain. Surprise is a process in the brain that brings various cognitive abilities, including attention and memory, into practical use. Furthermore, these abilities are about manipulating the input information in an optimized way. Memory is the ability to store information arriving at a specific time. Attention can be considered as the ability to filter redundant information and utilize the necessary data received at a specific time. A known marker of binding or transferring information between different brain regions which can be measured through electroencephalography (EEG) is Phase Amplitude Coupling (PAC) of the brain’s oscillatory activities. In this study, we investigate the dynamic behavior of PAC in oddball tasks, which trigger the process of surprise in the brain. The dataset used in our analysis consists of EEG data recorded for three groups of subjects, a group of healthy individuals, and two groups of Parkinson's patients, which are either ON or OFF Levodopa, which is the medication widely used for Parkinson’s disease (PD). Using the temporal dynamics of PAC, we provide explanations about the relationship between cognitive impairments caused by PD and the deficits induced by the medication. We also investigate the relation between theoretical surprise and PAC through analyzing data of different time windows for the three groups of subjects
  9. Keywords:
  10. Phase-Amplitude Coupling (PAC) ; Oddball Paradaigm ; Information Transfer ; Surprise ; Parkinson Disease ; Binding and Transferring Information

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