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3d Design of a Microfluidic Chip for Anticancer Drugs Screening

Hashemi, Maryam Sadat | 2022

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  1. Type of Document: M.Sc. Thesis
  2. Language: Farsi
  3. Document No: 55875 (06)
  4. University: Sharif University of Technology
  5. Department: Chemical and Petroleum Engineering
  6. Advisor(s): Mashayekhan, Shohreh; Saadatmand, Maryam
  7. Abstract:
  8. Nowadays, advanced and inexpensive pre-clinical methods for investigating the effects of anti-cancer drugs are expanding. One of the latest three-dimensional laboratory modeling for evaluating the effects of drugs is the use of tumor-on-chip technology, which actually models the physiological system of the body through three-dimensional scaffolds, multicellular cultures, and shaped vascular systems. In this study, three-dimensional culture of cancer cells was performed in the form of spheroids. A chip of U-shaped microstructures with and without gaps was used to trap cells and form cancer spheroids. We simulated the simultaneous effect of drug and oxygen concentration distribution inside the spheroid with Comsul multiphysics. the results showed that Creating a gap in the two-dimensional system leads to an increase in the average oxygen concentration changes and it decreases in the average drug concentration changes inside the spheroid. In the system with variable cell density, creating a gap leads to an increase in the average changes of both. Increasing the flow rate in the two-dimensional system leads to an increase in the average oxygen concentration changes and a reduction of drug average concentration change. In comparison, in three-dimensional system, both drug and oxygen concentration changes reduced. We concluded that in the three-dimensional system, the creation of gaps leads to a decrease in the average concentration of oxygen and drugs inside the spheroid and due to a further rising in drug delivery, tumor cell death increased
  9. Keywords:
  10. Multicellular Spheroids ; Microfluidic System ; COMSOL Software ; Anticancer Drugs ; Drug Delivery ; Drug Screening ; U-Shaped Microstructure ; Oxygen ; Three Dimensional Modeling ; Tumor-On-Chip

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