Loading...

Continuum Modeling of Biological Growth of Atheroma in Coronary

Hosseini, Majid | 2023

79 Viewed
  1. Type of Document: M.Sc. Thesis
  2. Language: Farsi
  3. Document No: 56408 (08)
  4. University: Sharif University of Technology
  5. Department: Mechanical Engineering
  6. Advisor(s): Firoozabadi, Bahar
  7. Abstract:
  8. Atherosclerosis is a vascular disorder caused by inflammation of the arterial wall. This inflammation leads to the accumulations of low-density lipoprotein (LDL) cholesterol, monocytes, macrophages and fat-laden foam cells at the site of inflammation, often referred to as plaque formation. This work uses a mathematical model for simulating the deposition of atheroma plaque in coronary arteries. In this study, the effect of time average wall shear stress (TAWSS), oscillatory shear index (OSI), non-Newtonian characteristics of blood and variable hematocrit values on the occurrence of atherosclerosis in a three-dimensional coronary artery was numerically investigated. Simulations was conducted in a 3-D coronary artery bifurcation using Fluent software. This model utilizes momentum equation to simulate transient blood flow along the lumen. Additionally, Darcy's law and Kedem-Katchalsky equations are employed to analyze plasma and species transport across the endothelium using the three-pore model. The mass balances of all substances in the model are implemented through convection-diffusion-reaction equations. The findings suggest the maximum Foam cells concentrations in the myocardial wall of the Left Anterior Descending (LAD) artery and outer wall of the Left Circumflex (LCX) artery; thereby indicating these two regions as particularly vulnerable to the early plaques development, which is consistent with the previous clinical research. Also, it is important to consider the non-Newtonian characteristics of blood flow in the bifurcations, as it has a direct influence on the time average wall shear stress (TAWSS) and the oscillatory shear index (OSI)
  9. Keywords:
  10. Artery Stenosis ; Coronary Bifurcation ; Hematocrit ; Low Density Lipoprotein (LDL) ; Time-Averaged Wall Shear Stress (TAWSS) ; Foam Cell ; Oscillatory Shear

 Digital Object List

 Bookmark

No TOC