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Regio- and diastereoselective synthesis of new dispirocyclopentanebisoxindoles using a three-component strategy

Matloubi Moghaddam, F ; Sharif University of Technology | 2023

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  1. Type of Document: Article
  2. DOI: 10.1016/j.tet.2023.133495
  3. Publisher: Elsevier Ltd , 2023
  4. Abstract:
  5. An efficient and facile one-pot, multi-component reaction for the regio- and diastereoselective synthesis of novel dispirocyclopentanebisoxindoles has been reported by a reaction between phenyl-2-(triphenylphosphoranylidene)ethanone and isatin derivatives. The great advantages of this synthetic protocol are the minimal reaction steps, short reaction time, and operational simplicity. In consequence, a variety of new dispirocyclopentanebisoxindole derivatives with potential medicinal applications were synthesized through one-pot and multi-component reaction in high to excellent yields. © 2023 Elsevier Ltd
  6. Keywords:
  7. Dispirocyclopentanebisoxindoles ; Green conditions ; Isatin derivatives
  8. Source: Tetrahedron ; Volume 141 , 2023 ; 00404020 (ISSN)
  9. URL: https://www.sciencedirect.com/science/article/pii/S0040402023002946