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Fabrication of pH and thermal dual-responsive hyperbranched copolymer grafted magnetic graphene oxide via surface-initiated RAFT-SCVP for controlled release of DOX

Kohestanian, M ; Sharif University of Technology | 2023

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  1. Type of Document: Article
  2. DOI: 10.1016/j.mtcomm.2023.105504
  3. Publisher: Elsevier Ltd , 2023
  4. Abstract:
  5. Herein, a novel stimuli-responsive magnetic graphene oxide/hyperbranched copolymer nanocomposites (GO@Fe3O4 @HBC) was prepared via mixing surface-initiated RAFT and self-condensing vinyl polymerization technique. In the first step, chain transfer monomer (CTM) was synthesized by the esterification reaction between 2-(dodecylthiocarbonothioylthio)− 2-methylpropionic acid (DDMAT) and 2-Hydroxyethyl methacrylate (HEMA). Besides, graphene oxide nanosheets were decorated with Fe3O4 nanoparticles. The surface of magnetic graphene oxide nanosheets was modified with 3-amino propyl (trimethoxysilyl) (APTS) and then the DDMAT was anchored to the surface of their nanosheets via amidification reaction. At last, smart hyperbranched poly (NIPAM-co-AA) was effectively grafted to the surface of magnetic graphene oxide using the SI-RAFT-SCVP technique. The chemical and physical structure of the synthesized GO@Fe3O4 @HBC were investigated by FT-IR, H NMR, GPC, TGA, DLS, CHN, VSM, UV-Vis, SEM, EDAX, and TEM. The synthesized GO@Fe3O4 @HBC was used as a nanocarrier. The drug delivery efficacy of this nanocarrier was investigated in terms of in vitro doxorubicin (DOX) release and MTT assay against HeLa cells, which confirms both acidic pH and thermo-sensitive behavior. The MTT assay also revealed that the nanocarrier without DOX was biocompatible having cell viability greater than 90% for HeLa cells. DOX-loaded nanocarrier showed high cytotoxic effect on HeLa Cells. © 2023
  6. Keywords:
  7. Drug delivery ; Magnetic nanosheets– RAFT-SCVP– Hyperbranched copolymer– poly (NIPAM-co-AA)
  8. Source: Materials Today Communications ; Volume 35 , 2023 ; 23524928 (ISSN)
  9. URL: https://www.sciencedirect.com/science/article/abs/pii/S2352492823001940