Loading...

A hybrid cartilage extracellular matrix-based hydrogel/poly (ε-caprolactone) scaffold incorporated with Kartogenin for cartilage tissue engineering

Mohsenifard, S ; Sharif University of Technology | 2023

0 Viewed
  1. Type of Document: Article
  2. DOI: 10.1177/08853282221132987
  3. Publisher: SAGE Publications Ltd , 2023
  4. Abstract:
  5. Despite extensive studies, hydrogels are unable to meet the mechanical and biological requirements for successful outcomes in cartilage tissue engineering. In the present study, beta cyclodextrin (β-CD)-modified alginate/cartilage extracellular matrix (ECM)-based interpenetrating polymer network (IPN) hydrogel was developed for sustained release of Kartogenin (KGN). Furthermore, the hydrogel was incorporated within a 3D-printed poly (ε-caprolactone) (PCL)/starch microfiber network in order to reinforce the construct for cartilage tissue engineering. All the synthesized compounds were characterized by H1-NMR spectroscopy. The hydrogel/microfiber composite with a microfiber strand size and strand spacing of 300 μm and 2 mm, respectively showed a compressive modulus of 17.2 MPa, resembling the properties of the native cartilage tissue. Considering water uptake capacity, degradation rate, mechanical property, cell cytotoxicity and glycosaminoglycan secretions, β-CD-modified hydrogel reinforced with printed PCL/starch microfibers with controlled release of KGN may be considered as a promising candidate for using in articular cartilage defects. © The Author(s) 2022
  6. Keywords:
  7. 3D printing ; Cartilage tissue engineering ; Interpenetrating polymer network ; Kartogenin ; Reinforcing hydrogel
  8. Source: Journal of Biomaterials Applications ; Volume 37, Issue 7 , 2023 , Pages 1243-1258 ; 08853282 (ISSN)
  9. URL: https://pubmed.ncbi.nlm.nih.gov/36217954