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Development and validation of an optimal GATE model for pencil beam scanning (pbs) proton beam delivery

Asadi, A ; Sharif University of Technology | 2023

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  1. Type of Document: Article
  2. DOI: 10.1109/ICBME61513.2023.10488665
  3. Publisher: Institute of Electrical and Electronics Engineers Inc , 2023
  4. Abstract:
  5. We conducted a study to explore the potential utility of the GATE Monte Carlo (MC) code as an independent tool for dose calculation. We established a unified framework for dose calculation in pencil beam scanning (PBS) proton therapy (PT). Using GATE, we modeled the SIEMENS IONTRIS active scanned-based PT system. To verify the model, we compared depth dose profiles obtained from the MC simulation with experimental date. Additionally, we utilized the TG-119 clinical test case from AAPM to assess the accuracy of treatment planning and delivery using proton beams. The results of the MC simulation demonstrated strong agreement with measurements, revealing a 2.3% in mean point-To-point, maximum relative error (RE) of 0.95% in range parameter, 3.4% in peak to entrance ratio and 0.852% in peak position. The average relative difference between the MC simulation and the experiment in terms of absorbed dose in the SOBP area was 0.93%±0.88%. The TG-119 phantom modeling results demonstrated excellent conformity compared to a commercial treatment planning system (TPS), with a 2.4% deviation in target mean dose. These findings confirm the reliability of GATE simulation as a Stand-in for quality assurance (QA) in PT. © 2023 IEEE
  6. Keywords:
  7. Monte Carlo simulation ; Pencil beam ; proton therapy
  8. Source: 2023 30th National and 8th International Iranian Conference on Biomedical Engineering, ICBME 2023 ; 2023 , Pages 471-474 ; 979-835035973-2 (ISBN)
  9. URL: https://www.sciencedirect.com/science/article/pii/S0939388922001027