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Perylene bisimide-based nanocubes for selective vapour phase ultra-trace detection of aniline derivatives

Soufi, G ; Sharif University of Technology | 2023

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  1. Type of Document: Article
  2. DOI: 10.1016/j.aca.2022.340632
  3. Publisher: Elsevier B.V , 2023
  4. Abstract:
  5. Rapid and selective detection of biomarkers at trace levels is a highly coveted objective in the early diagnosis of cancer. Herein, we disclose the design and synthesis of a polyhedral oligomeric silsesquioxane (POSS) substituted perylene diimide. This compound is fully characterized in solution by multi nuclear NMR, as well as in gas state by ESI-MS. Surprisingly, solid-state characterization revealed an unusual cubic morphology with particle dimensions of 80–160 nm. Fluorescence studies indicate that the bulky POSS units effectively prevent perylene's aggregation caused quenching, yielding quantum yields as high as 92%. Exposing the sensor droplet-cast on quartz to anline and o-toluidine, two important biomarkers for lung cancer, results in very highly reproducible, reversible and selective fluorescence quenching responses, with LODs as low as 19 and 8 ng L−1, and linear ranges of 65–350 and 25–450 ng L−1 respectively. Mechanistic investigations point to photoinduced electron transfer (PET) as the operative pathway responsible for fluorescence quenching. © 2022 Elsevier B.V
  6. Keywords:
  7. Aniline derivatives ; Fluorescence quenching ; Perylene bisimide nanocubes ; Photoinduced electron transfer ; Polyhedral oligomeric silsesquioxane
  8. Source: Analytica Chimica Acta ; Volume 1238 , 2023 ; 00032670 (ISSN)
  9. URL: https://www.sciencedirect.com/science/article/abs/pii/S000326702201203X