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Investigation of the Effect Of Ph on Loading and Release of Doxorubicin in Aluminum Fumarate Metal-Organic Framework Modified by Garlic Extract

Ojaghi, Amir Hossein | 2023

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  1. Type of Document: M.Sc. Thesis
  2. Language: Farsi
  3. Document No: 57192 (03)
  4. University: Sharif University of Technology
  5. Department: Chemistry
  6. Advisor(s): Bagherzadeh, Mojtaba
  7. Abstract:
  8. In this study, the metal-organic framework of aluminum fumarate was synthesized in water and garlic extract. To characterize and investigate the structural differences, X-ray diffraction, infrared spectroscopy, X-ray photoelectron spectroscopy, field emission scanning electron microscopy, transmission electron microscopy, and nitrogen gas adsorption porosimetry were used. Drug loading results showed that in physiological and acidic environments, the presence of garlic extract in the MOF pores increased drug loading by up to 20% as these compounds act as nanoreactors enhancing drug-MOF interactions. CCK-8 toxicity test results showed that at a concentration of 100 µg.mL-1 of the synthesized metal-organic frameworks, the presence of garlic extract increased cell viability by 15.7%. Drug release results indicated that garlic extract compounds with increased electron density and steric hindrance around the metal centers of aluminum fumarate metal-organic frameworks, and reduced the release rate. Drug release modeling was performed using zero-order, first-order, Higuchi, Korsmeyer-Peppas, and Weibull models. The Weibull model had the highest coefficient of determination values and showed values above 0.95 in all 36 experimental samples. The Weibull model demonstrated that the drug release rate decreased over time at pH values of 5.6, 7.4, and 8.6, indicating that the main mechanism of drug release from the systems is Fickian diffusion
  9. Keywords:
  10. Aluminum Fumarate ; Metal-Organic Framework ; Natural Extract ; Doxorubicin ; Effect of Ph on Loading ; Effect of pH on Release ; Nanoreactors ; Drug Loading

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