Loading...

Optimization and Continuous Synthesis of Medicines Utilizing Catalysts Through a Micro-Reactor System

Bastan, Farzad | 2024

0 Viewed
  1. Type of Document: Ph.D. Dissertation
  2. Language: Farsi
  3. Document No: 57458 (06)
  4. University: Sharif University of Technology
  5. Department: Chemical and Petroleum Engineering
  6. Advisor(s): Kazemeini, Mohammad
  7. Abstract:
  8. In order to fabricate batch and continuous systems to synthesize Pirfenidone (PFD), Solidwork and COMSOL software were used. Effects of parameters on reaction yield including; microreactors, micromixer, solvents, temperature, reaction time, and catalysts were understudied. Moreover, FTIR, NMR and HPLC analyses used to evaluate the prepared PFD. Its yield in microfluidic (30.5 %) was higher than that of batch (17.1 %) reactor. Besides, reaction yield in the presence of DMSO was higher than DMF in both reactors. It was shown that, adding a micromixer enhanced reaction time. leading to a higher PFD yield. Nonetheless, the yield was reduced by enhancing the temperature when DMF was utilized. Additionally, the traditional synthesis method of PFD in a batch system, which reached a yield of 53.7% after 19 h, now reached 30.5% in a microreactor under similar conditions within 40 min. Utilizing the Design Expert Software, the results revealed a maximum overall reaction yield of 31% achieved at reactant ratio of K2CO3 to 2-hydroxy-5-methylpyridine of 7, Temperature of 160 ℃ and reaction time of 60 min completely matching the experimental results. Ultimately, kinetics of PFD was understudied incorporating a Molecular Dynamic Software where a new 3-steps mechanism was proposed. Moreover, a power law model revealed an empirical reaction order of 1.45
  9. Keywords:
  10. Pharmaceutical Industry ; Pirfenidone Drug ; Microreactor ; Micromixer ; Catalyst ; Experimental Design ; Mechanism ; Design Expert Software

 Digital Object List

 Bookmark

No TOC