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Drug Delivery to the Brain for Parkinson's Disease Treatment Using Ultrasound Waves

Abarashi, Arman | 2024

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  1. Type of Document: M.Sc. Thesis
  2. Language: Farsi
  3. Document No: 57924 (08)
  4. University: Sharif University of Technology
  5. Department: Mechanical Engineering
  6. Advisor(s): Ahmadiyan, Mohamad Taghi; Fallah, Famida
  7. Abstract:
  8. Parkinson's disease (PD) is a neuromuscular disorder in which the dopamine-producing neurons in the brain (dopaminergic neurons) gradually deteriorate, leading to a reduction in the available dopamine in the brain, which is the cause of the disease. This condition can result in neurological and muscular issues, as well as dementia. The risk of dementia in Parkinson's patients is 6 to 8 times higher than in the general population, and over time, its prevalence reaches 80%. Besides controlling medications, there is currently no definitive treatment for neurodegenerative diseases such as Parkinson's, Alzheimer's, and Multiple System Atrophy (MSA). One of the major challenges in drug delivery to the brain is crossing the blood-brain barrier (BBB). Numerous studies have been conducted on applying ultrasound waves to the brain to disrupt the BBB and facilitate drug passage. As a result, using these waves to transfer dopamine through the BBB could potentially provide a solution to Parkinson's disease. The goal of this project was to analyze how drugs are transported from blood vessels exposed to ultrasound waves to brain regions through the BBB, both in simulation and experimental settings. To this end, endothelial cells, which make up the walls of the BBB, were cultured in a laboratory environment, and two drugs, curcumin and FITC, representing hydrophobic and hydrophilic drugs respectively, were tested on these cells. Ultrasound waves were applied to attempt to open the barrier, and afterward, we examined the extent of drug passage through it. Additionally, the opening of the BBB and the passage of these drugs were simulated using VMD and Material Studio software
  9. Keywords:
  10. Parkinson Disease ; Blood Brain Barrier ; Ultrasonic Waves ; Drug Delivery ; Alzheimer ; Dopaminergic Treatment

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