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Optimization of Biomechanical and Drug Delivery Functions in Engineered Biomaterials In Order to Repair Tissues Exposed to Mechanical Tensions

Kalantarnia, Farnoosh | 2021

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  1. Type of Document: M.Sc. Thesis
  2. Language: Farsi
  3. Document No: 58092 (08)
  4. University: Sharif University of Technology
  5. Department: Mechanical Engineering
  6. Advisor(s): Shamloo, Amir
  7. Abstract:
  8. Articular cartilage is connective tissue without any blood vessels or nerves that severely limit its ability to regenerate and repair itself. Although treatments for cartilage repair have been developed, none of them have had satisfactory results. Among modern treatment methods, tissue engineering has attracted a lot of attention. As a non-invasive alternative to treatment and drug delivery to cartilage, thermosensitive scaffolds can provide a porous structure for cell growth, migration, and proliferation. In this study, a theromsensitive and injectable hydrogel was designed and optimized using beta glycerophosphate for controlled release of curcumin. Initially, different ratios of chitosan and bacterial nanocellulose polymers were selected as a substrate for transporting curcumin-containing microspheres. The properties of this system were evaluated by various factors such as gelling percentage, gelling time, water absorption, porosity, biodegradability, and mechanical properties. After adding microspheres, drug release, antibacterial, and biocompatibility properties were measured. The results showed that the addition of bacterial cellulose to the temperature-sensitive system of chitosan/beta-glycerophosphate increased the compression modulus of the hydrogel up to 8 times compared to similar studies. Also, results showed that the hydrogel made with volume ratios of 3 and 4 of chitosan- bacterial cellulose showed better performance in the tests and was selected as the optimal sample. This hydrogel system has a suitable porosity size (104 micrometers) and water absorption up to 12 times its dry weight. Although hydrogels made with volumetric ratios of 5 and 2 chitosan-bacterial cellulose showed better biocompatibility properties, hydrogels made with ratios of 3 and 4 were not toxic to cells and their controlled degradation rate (55% up to 30 days) provides suotable conditions for controlled release of curcumin and tissue repair
  9. Keywords:
  10. Cartilage Tissue Engineering ; Thermosensitive Hydrogels ; Chitosan ; Bacterial Cellulose ; Drug Delivery ; Curcumin ; Mechanical Stress ; Cartilage Tissue Repair

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