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Graphic: Graph-based hierarchical clustering for single-molecule localization microscopy
, Article 18th IEEE International Symposium on Biomedical Imaging, ISBI 2021, 13 April 2021 through 16 April 2021 ; Volume 2021-April , 2021 , Pages 1892-1896 ; 19457928 (ISSN); 9781665412469 (ISBN) ; Aziznejad, S ; Unser, M ; Sage, D ; Sharif University of Technology
IEEE Computer Society
2021
Abstract
We propose a novel method for the clustering of point-cloud data that originate from single-molecule localization microscopy (SMLM). Our scheme has the ability to infer a hierarchical structure from the data. It takes a particular relevance when quantitatively analyzing the biological particles of interest at different scales. It assumes a prior neither on the shape of particles nor on the background noise. Our multiscale clustering pipeline is built upon graph theory. At each scale, we first construct a weighted graph that represents the SMLM data. Next, we find clusters using spectral clustering. We then use the output of this clustering algorithm to build the graph in the next scale; in...
Numerical Modeling of Liquid Jet Breakup Using SPH Method
, M.Sc. Thesis Sharif University of Technology ; Morad , Mohammad Reza (Supervisor) ; Omidvar, Pourya (Supervisor)
Abstract
Smoothed Particle Hydrodynamics (SPH) is a numerical Lagrangian meshless method which has numerous applications in astrophysics, hydrodynamics, free-surface flows, jets and sprays formation. Atomization of continuum liquid to fine droplets or in other words, liquid breakup processes are emerged in many engineering applications such as fuel sprays inside the combustion chamber of internal combustion engines that sizes of produced sprays significantly influence the engine’s efficiency. This research is accomplished to investigate the one-phase and two-phase flows of liquid jet breakup. For this aim, an open source code called SPHysics which solves the flow field by SPH method is utilized. This...
Stability of Cantilevered Beams Subjected to Random Follower Forces
, M.Sc. Thesis Sharif University of Technology ; Haddadpour, Hassan (Supervisor)
Abstract
In Mechanical systems there is always possibility of statical and dynamical following force. These forces are generated due to aerodynamic pressure, temperature gradient, and jet thrusters. In unstabel systems, if the value of this force exceeds a certaim amount the system becomes unstable. This value is called as critical force. In order to analyse these systems, fisrt of all, the governing dynamic equations are obtained by using the Galerkin-Ritz method. Then, by utilising the modal analysis, these equation are uncoupled. And then, the Ito set of equations are derived. By utilising the Lyapanov method, Ito equations are transfered to another state. and using the fokker-planc equation the...
A System Dynamics Model to Find Optimal Policies for competition and Development of Online Question and Answer Knowledge Markets
, M.Sc. Thesis Sharif University of Technology ; Kianfar, Farhad (Supervisor)
Abstract
Knowledge markets where knowledge transactions take place are today see increasingly expansion by influences of the Internet and the importance of knowledge. A competitive space, thus, has been placed among different enterprises step in knowledge markets. With no exception to this general rule, one of these markets covers online question – answer knowledge market. Google Answers is a proposed website in this area which, although being of interest in recent decades, its activities ended in 2006 for several reasons. Significantly, these markets consist of many factors with interrelated effects on each other and this leads to complexity of systems. Therefore, in order to study these markets, it...
Buckling behavior of composite triangular plates
, Article International Journal of GEOMATE ; Volume 2, Issue 2 , 2012 , Pages 253-260 ; 21862982 (ISSN) ; Heydarnia, E ; Amani, P ; Sharif University of Technology
GEOMATE International Society
2012
Abstract
This paper is to do a brief research on the buckling behavior of composite triangular plates with various edge boundary conditions and in-plane loads. It may be regarded as a right and simple numerical method for the analysis of composite triangular thin plate using the natural Area coordinates. Previous studies on the solution of triangular plates with different boundary conditions were mostly based on the Rayleigh-Ritz principle which is performed in the Cartesian coordinate. In this method, the energy functional of a general triangular plate is derived and the Rayleigh-Ritz method is utilized to derive the governing eigenvalue equation for the buckling problem. The geometry is presented...
A three-winding coupled-inductor high step-up boost converter with an active-clamp circuit
, Article 12th Power Electronics, Drive Systems, and Technologies Conference, PEDSTC 2021, 2 February 2021 through 4 February 2021 ; 2021 ; 9780738111971 (ISBN) ; Beiranvand, R ; Zolghadri, M ; Sharif University of Technology
Institute of Electrical and Electronics Engineers Inc
2021
Abstract
A new high step-up boost converter with an active clamp circuit to eliminate voltage spike caused by leakage inductor is introduced in this paper. The introduced power converter has a high voltage gain for variable input voltage from 48V to 80V. Since both main and auxiliary switches turn on with zero voltage switching (ZVS) and all the diodes turn off under zero current switching (ZCS) condition, switching losses and EMI noises are strongly degraded. Therefore, the converter's efficiency is improved significantly. Simulation results show a 96.4% peak efficiency and 95.4% average efficiency. The proposed topology is suitable for low-input-voltage and low-output power applications such as...
A new high step-up interleaved LLC converter
, Article 12th Power Electronics, Drive Systems, and Technologies Conference, PEDSTC 2021, 2 February 2021 through 4 February 2021 ; 2021 ; 9780738111971 (ISBN) ; Beiranvand, R ; Zolghadri, M ; Sharif University of Technology
Institute of Electrical and Electronics Engineers Inc
2021
Abstract
In this study, a new LLC resonant converter for high-voltage high-power applications is introduced. The introduced power converter is a two-phase interleaved full-bridge based that uses a transformer with secondary and tertiary windings to obtain higher output voltage. Zero voltage switching (ZVS) at MOSFETs turn on and zero current switching (ZCS) for all the output diodes at turn off are achieved for a wide range of input voltage (100 V-200 V) and output power (200 W-1500 W) variations. Simulation results show a 95% peak efficiency. © 2021 IEEE
Treatment of wastewatercontaining carbohydrates usingpichia saitoi culture
, Article International Journal of Engineering, Transactions B: Applications ; Volume 17, Issue 3 , 2004 , Pages 209-218 ; 1728-144X (ISSN) ; Yaghmaei, S ; Maghsoodi, V ; Sharif University of Technology
National Research Center of Medical Sciences
2004
Abstract
Treatment of wastewater containing carbohydrates by Pichia saitoi growing on beet molasses was investigated in a well-mixed continuous tank as an alternative to bulking control. The yeast strain that used in this work was isolated from non-alcoholic beverage industrial wastewater, with a view on TOC removal compared with other strains in previous study.In this research the isolated yeast showed high COD and TOC removal at three hydraulic retention times, HRT= 48, 24 and 18 hours.Maximum COD and TOC reductions were obtained at HRT=48 hours, which were 96% and 88%, respectively.The influent COD and TOC were 2500 and 148 mg/1, respectively.The pH maintained for synthetic wastewater was about...
A lightweight mutual authentication scheme for vanets between vehicles and RSUs
, Article ISeCure ; Volume 15, Issue 3 , 2023 , Pages 77-89 ; 20082045 (ISSN) ; Mohajeri, J ; Salmasizadeh, M ; Sharif University of Technology
Iranian Society of Cryptology
2023
Abstract
Vehicular Ad-hoc Networks (VANETs) have emerged as part of Intelligent Transportation Systems (ITS), offering the potential to enhance passenger and driver safety, as well as driving conditions. However, VANETs face significant security challenges and various attacks due to their wireless nature and operation in free space. Mutual authentication between vehicles and RSUs is one of the most, if not the most, critical security requirements in VANETs. In this process, maintaining resource authenticity, data authenticity and preserving users’ privacy, are key concerns. This paper proposes a pseudonym-based authentication scheme for VANETs, built upon existing approaches. The proposed scheme not...
Wind-tolerant optimal closed loop controller design for a domestic atmospheric research airship
, Article Mechanics Based Design of Structures and Machines ; 2020 ; Pourtakdoust, S. H ; Pazooki, F ; Sharif University of Technology
Taylor and Francis Inc
2020
Abstract
Airships are inherently sensitive to random atmospheric disturbances that could potentially make their data gathering and observation missions a formidable task. In this context robust closed loop feedback controllers are important. The present study is therefore focused on optimal feedback controller design of an indigenous domestically designed airship (DA) for added robustness against atmospheric disturbances. While the general airship six degrees of freedom (6DoF) governing equations of motion are mathematically nonlinear, one often needs to resort to local linearization methods to benefit from proven linear closed loop controller (CLC) design approaches. In this sense an optimal linear...
Wind-tolerant optimal closed loop controller design for a domestic atmospheric research airship
, Article Mechanics Based Design of Structures and Machines ; Volume 50, Issue 6 , 2022 , Pages 2046-2066 ; 15397734 (ISSN) ; Pourtakdoust, S. H ; Pazooki, F ; Sharif University of Technology
Taylor and Francis Ltd
2022
Abstract
Airships are inherently sensitive to random atmospheric disturbances that could potentially make their data gathering and observation missions a formidable task. In this context robust closed loop feedback controllers are important. The present study is therefore focused on optimal feedback controller design of an indigenous domestically designed airship (DA) for added robustness against atmospheric disturbances. While the general airship six degrees of freedom (6DoF) governing equations of motion are mathematically nonlinear, one often needs to resort to local linearization methods to benefit from proven linear closed loop controller (CLC) design approaches. In this sense an optimal linear...
Targeted drug delivery of microbubble to arrest abdominal aortic aneurysm development: a simulation study towards optimized microbubble design
, Article Scientific Reports ; Volume 10, Issue 1 , 2020 ; Ebrahimi, S ; Amani, A ; Fallah, F ; Sharif University of Technology
Nature Research
2020
Abstract
Abdominal aortic aneurysm (AAA) is an irreversible bulge in the artery with higher prevalence among the elderlies. Increase of the aneurysm diameter by time is a fatal phenomenon which will lead to its sidewall rupture. Invasive surgical treatments are vital in preventing from AAA development. These approaches however have considerable side effects. Targeted drug delivery using microbubbles (MBs) has been recently employed to suppress the AAA growth. The present study is aimed to investigate the surface adhesion of different types of drug-containing MBs to the inner wall of AAA through ligand-receptor binding, using fluid-structure interaction (FSI) simulation by using a patient CT-scan...
Effect of material and population on the delivery of nanoparticles to an atherosclerotic plaque: a patient-specific in silico study
, Article Langmuir ; Volume 37, Issue 4 , 2021 , Pages 1551-1562 ; 07437463 (ISSN) ; Shamloo, A ; Barzegar, S ; Forouzandehmehr, M ; Sharif University of Technology
American Chemical Society
2021
Abstract
Coronary artery disease (CAD) is the prevalent reason of mortality all around the world. Targeting CAD, specifically atherosclerosis, with controlled delivery of micro and nanoparticles, as drug carriers, is a very proficient approach. In this work, a patient-specific and realistic model of an atherosclerotic plaque in the left anterior descending (LAD) artery was created by image-processing of CT-scan images and implementing a finite-element mesh. Next, a fluid-solid interaction simulation considering the physiological boundary conditions was conducted. By considering the simulated force fields and particle-particle interactions, the correlation between injected particles at each cardiac...
Drug delivery performance of nanocarriers based on adhesion and interaction for abdominal aortic aneurysm treatment
, Article International Journal of Pharmaceutics ; Volume 594 , 2021 ; 03785173 (ISSN) ; Vatani, P ; Amani, A ; Shamloo, A ; Sharif University of Technology
Elsevier B.V
2021
Abstract
Targeted drug delivery using nanocarriers (NCs) is one of the novel techniques that has recently been used to improve drug delivery to the Abdominal aortic aneurysm (AAA) disease. The purpose of this study is to evaluate the surface density of NCs (SDNC) adhered via ligand-receptor binding to the inner wall of AAA. For this purpose, fluid–structure interaction (FSI) analysis was first performed for the patient-specific and ideal AAA models. Then, by injecting NCs into the aortic artery, the values of SDNC adhered to and interacted with AAA wall were obtained. Two types of NCs, liposomes, and solid particles in four different diameters, were used to investigate the effect of the diameter and...
Particles focusing and separation by a novel inertial microfluidic device: divergent serpentine microchannel
, Article Industrial and Engineering Chemistry Research ; Volume 61, Issue 38 , 2022 , Pages 14324-14333 ; 08885885 (ISSN) ; Shamloo, A ; Vatani, P ; Ebrahimi, S ; Sharif University of Technology
American Chemical Society
2022
Abstract
Microfluidic experiments have found wide applications in medical sciences and engineering, such as cell separation and focusing. In the present study, focusing and separation of particles with different sizes and densities were investigated by designing inertial microfluidic devices. The microfluidic channel is designed by analyzing the induced forces on the particles. In the designing process, the objective was to focus and separate the particles in the shortest length of the channel with the lowest possible cycles and high efficiency. The simulation is then used for analyzing the two proposed geometries to evaluate their particle separation and focusing ability, named convergent and...
Developing an Efficient Approach for Improving Operational Resilience of Power Distribution Network in Facing with Earthquake
, M.Sc. Thesis Sharif University of Technology ; Fotuhi Firuzabad, Mahmud (Supervisor)
Abstract
The design and operation of energy systems infrastructure is typically based on key reliability criteria such as system security and adequacy. Nowaday, with the rise of unexpected events and events such as floods, earthquakes, storms, and other natural phenomena can affect the performance of energy infrastructure. Given the low probability of these events, reliability studies and relevant criteria cannot guarantee that an energy infrastructure can respond well to these events. Investigating the ability of energy infrastructures to deal with these phenomena is divided into resilience studies. To overcome these challenges, this thesis has attempted to detail some of these natural events....
The design and operation of energy systems infrastructure is typically based on key reliability criteria such as system security and adequacy. Nowaday, with the rise of unexpected events and events such as floods, earthquakes, storms, and other natural phenomena can affect the performance of energy infrastructure. Given the low probability of these events, reliability studies and relevant criteria cannot guarantee that an energy infrastructure can respond well to these events. Investigating the ability of energy infrastructures to deal with these phenomena is divided into resilience studies. To overcome these challenges, this thesis has attempted to detail some of these natural events....
Designing a sustainable reverse supply chain network for COVID-19 vaccine waste under uncertainty
, Article Computers and Industrial Engineering ; Volume 174 , 2022 ; 03608352 (ISSN) ; Fallahi, A ; Varmazyar, M ; Fathi, M ; Sharif University of Technology
Elsevier Ltd
2022
Abstract
The vast nationwide COVID-19 vaccination programs are implemented in many countries worldwide. Mass vaccination is causing a rapid increase in infectious and non-infectious vaccine wastes, potentially posing a severe threat if there is no well-organized management plan. This paper develops a mixed-integer mathematical programming model to design a COVID-19 vaccine waste reverse supply chain (CVWRSC) for the first time. The presented problem is based on minimizing the system's total cost and carbon emission. The uncertainty in the tendency rate of vaccination is considered, and a robust optimization approach is used to deal with it, where an interactive fuzzy approach converts the model into...
A mathematical and experimental analysis of role of ultrasonic wave radiation on relative permeabilties in gravity drain
, Article 73rd European Association of Geoscientists and Engineers Conference and Exhibition 2011: Unconventional Resources and the Role of Technology. Incorporating SPE EUROPEC 2011 ; Volume 7 , May , 2011 , Pages 5104-5108 ; 9781617829666 (ISBN) ; Keshavarzi, B ; Ghazanfari, M ; Ghotbi, C ; Amani, M ; Sharif University of Technology
Society of Petroleum Engineers
2011
Abstract
This work concerns with experimental and analytical investigation of role of ultrasonic wave radiation in relative permeability of both wetting and non-wetting phases in a free gravity drainage process in porous media under the influence of ultrasonic wave. Glass beads ranged from 70 to 100 mesh sizes were packed and used in the tests. The working fluids consist of distilled water, kerosene and Doroud and Paidar crude oils as wetting and air as non-wetting phase. The measured oil recovery data along with Hagoort (1984) backward methodology were used to determine and to compare the relative permeability of wetting phases in presence and absence of ultrasonic radiation. In addition, the...
Design, Simulation and Construction of a Microfluidic Device for the Purpose of Target Cells Separation and DNA Extraction
, M.Sc. Thesis Sharif University of Technology ; Shamloo, Amir (Supervisor) ; Nouri Borujerdi, Ali (Supervisor)
Abstract
Today, microfluidic experiments have found wide applications in medical sciences, engineering, and chemistry. Because of their small size, microfluidic devices help us to be able to use very little amount of sample for the experiments and also easily control and observe the under-experiment fluid. One of the most important applications of these devices is the separation of cancer cells in blood for counting their number and DNA genetic studies. In the current project we have tried to do the separation of cancer cells from other cells by designing an inertia microchannel. For this purpose, in the first step a geometry for the channel is designed with analyzing the induced forces on the cells....
Dioxo and oxo-peroxo molybdenum(VI) complexes bearing salicylidene 2-picoloyl hydrazone: Structures and catalytic performances
, Article Polyhedron ; Volume 53 , 2013 , Pages 223-229 ; 02775387 (ISSN) ; Zare, M ; Amani, V ; Ellern, A ; Keith Woo, L ; Sharif University of Technology
2013
Abstract
Molybdenum complexes bearing a salicylidene 2-picoloyl hydrazone ligand have been synthesized and characterized. The salicylidene 2-picoloyl hydrazone ligand (H2sal-phz) was prepared by reaction of picoloyl hydrazine with salicylaldehyde. Reaction of H2sal-phz with MoO2(acac) 2 generates the dioxo molybdenum complex MoO2(sal-phz) (CH3OH). Treatment of MoO3 in the presence of H 2O2 with H2sal-phz produces the oxo-peroxo molybdenum(VI) complex MoO(O2)(sal-phz)(CH3OH). The new compounds were characterized by 1H NMR and IR spectroscopies, and elemental analysis. The complexes were also characterized by single crystal X-ray diffraction crystallography. The complexes were evaluated for epoxidation...