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b-aminocarbonyls
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Synthesis of β- Amino Carbonyl Compounds in Solvent-free Condition in the Presence of SiCl4 And Synthesis of Benzothiazole Derivatives
, M.Sc. Thesis Sharif University of Technology ; Mahmoodi Hashemi, Mohammad (Supervisor) ; Azizi, Najmeddin (Supervisor)
Abstract
SiCl4 catalyzed Michael addition reaction of aliphatic and aromatic amines with different α,β- unsaturated compounds and one-pot three component Mannich reaction under solvent-free condition were investigated. β-amino carbonyl compound were synthesized in high yield in short reaction time. Furthermore, in the Mannich reaction good yield and excellent stereoselectivity were observed. In addition, the synthesis of 2-substituted benzothiazoles from aromatic aldehydes and 2 aminothiophenol in moderate to excellent yields in water in the presence of PTSA catalyst (10 mol%). This method provides a simple and efficient protocol in terms of mild reaction conditions, clean reaction profiles, small...
Michael Addition of Aromatic Amines and Synthesis Some Derivatives of Thiomorpholins
, M.Sc. Thesis Sharif University of Technology ; Mahmoudi Hashemi, Mohammad (Supervisor) ; Ziyaei Halimehjani, Azim (Supervisor)
Abstract
This project investigates on synthesis of β-amino carbonyl compounds with new approach to become closer to green chemistry principals.In this project, we investigated the synthesis of β-amino carbonyl compounds with aromatic amines and electron deficient alkenes in the Michael reaction using boric acid and glycerol in water as a green media. High yields of the products and easy handling are some advantages of this procedure. Also, we investigated the Michael reaction in different solvents and temperatures but gave better results in the aqueous media. Moreover, thiomorpholine derivatives were synthesized using this method to give excellent yield.