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    Designing an Intelligent System to Analyze Electrograms of Induced Pluripotent Stem Cell-Derived Cardiomyocytes

    , M.Sc. Thesis Sharif University of Technology Golgooni, Zeinab (Author) ; Rabiee, Hamid Reza (Supervisor) ; Soleymani, Mahdieh (Supervisor) ; Pahlavan, Sara (Co-Advisor)
    Ability to differentiate induced pluripotent stem cells to cardiomycocytes has attracted attentions,considering crucial role of the heart in the human body and great potential applications of these cells like disease modeling, new treatment methods and basic research. We are able to analyze the performance of beating cells through recording extracellular field potentials of cardiomyocytes using multi-electrode array (MEA) technology. This analysis is an essential step to use cardiac cells in any future development and experiment. Currently, the electrophysiology experts analyze recorded extracellular field potentials of induced cardiomyocytes by observing all the episodes of each record.... 

    Study and Fabrication of a Microfluidic System to Investigate Stem Cell Differentiation

    , M.Sc. Thesis Sharif University of Technology Motmaen Esfahani, Shayan (Author) ; Vosoughi, Manouchehr (Supervisor) ; Alemzadeh, Iran (Supervisor)
    In recent years, many studies have conducted research about stem cells due to their prominent features such as proliferation and differentiation. By changing the specific parameters of the cellular micro-environment, it is possible to determine the stem cells fate and thereby use them in medical affairs. For this purpose, various devices and methods have been designeds such as microfluidic devices and scaffolds. The microfluidic devices has been especially focuced in the researchs due to their unique features, like the possibility of testing with small amounts of samples, the creation and control of low cost cellular micro-environment and low practical time. Two-dimensional scaffolds made up...