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    Modeling of Cancer Progression by Using Evolutionary Game Theory

    , M.Sc. Thesis Sharif University of Technology Malekian Boroujeni, Negin (Author) ; Habibi, Jafar (Supervisor)
    Abstract
    Mathematical modeling and computer simulation are powerful tools to help cancer research because they provide a good insight of cancer progression and an efficient framework to test biological hypothesis. Most of the previous studies ignored many intracellular communication between tumor cells. Gap junction is one of the interaction ways between tumor cells which plays a crucial role in cancer progression. In the first phase of this thesis, a model of intracellular communication through gap junction using evolutionary game theory scoring is proposed. In the second phase of this thesis, cancer is modeled by Markov decision process (MDP). Given that considering nutrient level constant is one... 

    Monitoring of Ion Implanter Radiation

    , M.Sc. Thesis Sharif University of Technology Malekian Sourki, Mehrdad (Author) ; Rashidian, Bizhan (Supervisor)
    Abstract
    X-ray radiation is an ionizing radiation that can be produced under some conditions in an ion implanter and can have significant effects on equipment and personnel health. In this dissertation, we first examine the properties of ionizing radiations and their effects of electronic devices and discuss the general properties of common detectors. Next, Using Silvaco TCAD and GEANT4 we will simulate the interaction of ionzing radiation with energies up to 300 keV with electronic devices including a commercial off the shelf photo diode and a specialized x-ray detector and show that these devices can efficiently reveal informations of a radiation source to the user. Also, it has been shown that... 

    Distance Coluring Graphs

    , M.Sc. Thesis Sharif University of Technology Malekian, Mahdieh (Author) ; Mahmoodian, Ebadollah (Supervisor)

    On The Existence of Arithmetic Progressions In Subsets of Integers

    , M.Sc. Thesis Sharif University of Technology Malekian, Reihaneh (Author) ; Alishahi, Kasra (Supervisor) ; Hatami, Omid (Supervisor)
    Abstract
    Suppose that A is a large subset of N. It is interesting to think about the arithmetic progressions in A.In 1936, Erdos and Turan conjectured that for > 0 and k 2 N, there exists N = N(k; ) that for all subsets A {1; 2; : : : ;N}, if lAl N, A has a nontrivial arithmetic progression of length k. Roth proved the conjecture for k = 3 in 1953. In 1969, Szemeredi proved the case k = 4 and in 1975, he gave a combinatorial proof for the general case. In 1977, using ergodic theory, Furstenberg gave a different proof for the Erdos-Turan conjecture (or Szemeredi Theorem!) and finally Gowers found another proof for the Szemeredi theorem, which was an elegant generalization of the Roth’s proof for k =... 

    Experimental and Numerical Study of a Shape Memory Alloy Wire Rope Behavior in Release Mechanism

    , M.Sc. Thesis Sharif University of Technology Malekian, Ali (Author) ; Naghdabadi, Reza (Supervisor) ; Arghavani Hadi, Jamal (Supervisor)
    Abstract
    Smart materials are able to change their physical properties under various environmental conditions. Shape memory alloys (SMA) are relatively new smart materials that can respond to environmental stimuli e.g., heat, electricity, etc. Unique behaviors of SMAs, called shape memory effect and superelasticity, have motivated many applications in various fields of study (aerospace, medical, civil engineering, etc.). Although the behavior of SMAs is complicated, modeling and utilizing these materials have been receiving much attention in the past 20 years. Since a cable tolerate more tension than a wire or rod, the shape memory alloy cables could have a broad range of potential applications.... 

    δ M formalism: a new approach to cosmological perturbation theory in anisotropic inflation

    , Article Journal of Cosmology and Astroparticle Physics ; Volume 2018, Issue 3 , 2018 ; 14757516 (ISSN) Talebian Ashkezari, A ; Ahmadi, N ; Abolhasani, A. A ; Sharif University of Technology
    Institute of Physics Publishing  2018
    Abstract
    We study the evolution of the metric perturbations in a Bianchi background in the long-wavelength limit. By applying the gradient expansion to the equations of motion we exhibit a generalized "Separate Universe" approach to the cosmological perturbation theory. Having found this consistent separate universe picture, we introduce the δ M formalism for calculating the evolution of the linear tensor perturbations in anisotropic inflation models in almost the same way that the so-called δ N formula is applied to the super-horizon dynamics of the curvature perturbations. Similar to her twin formula, δ N, this new method can substantially reduce the amount of calculations related to the evolution... 

    α-Helical antimicrobial peptide encapsulation and release from boron nitride nanotubes: A computational study

    , Article International Journal of Nanomedicine ; Pages 4277-4288 , Volume 16 , 2021 ; 11769114 (ISSN) Zarghami Dehaghani, M ; Yousefi, F ; Bagheri, B ; Seidi, F ; Mashhadzadeh, A. H ; Rabiee, N ; Zarrintaj, P ; Mostafavi, E ; Saeb, M. R ; Kim, Y. C ; Sharif University of Technology
    Dove Medical Press Ltd  2021
    Abstract
    Introduction: Antimicrobial peptides are potential therapeutics as anti-bacteria, anti-viruses, anti-fungi, or anticancers. However, they suffer from a short half-life and drug resistance which limit their long-term clinical usage. Methods: Herein, we captured the encapsulation of antimicrobial peptide HA-FD-13 into boron nitride nanotube (BNNT) (20,20) and its release due to subsequent insertion of BNNT (14,14) with molecular dynamics simulation. Results: The peptide-BNNT (20,20) van der Waals (vdW) interaction energy decreased to −270 kcal·mol−1 at the end of the simulation (15 ns). However, during the period of 0.2–1.8 ns, when half of the peptide was inside the nanotube, the... 

    r-Strong edge colorings of graphs

    , Article Discrete Mathematics ; Volume 306, Issue 23 SPEC. ISS , 2006 , Pages 3005-3010 ; 0012365X (ISSN) Akbari, S ; Bidkhori, H ; Nosrati, N ; Sharif University of Technology
    Elsevier  2006
    Abstract
    Let G be a graph and for any natural number r, χs ′ (G, r) denotes the minimum number of colors required for a proper edge coloring of G in which no two vertices with distance at most r are incident to edges colored with the same set of colors. In [Z. Zhang, L. Liu, J. Wang, Adjacent strong edge coloring of graphs, Appl. Math. Lett. 15 (2002) 623-626] it has been proved that for any tree T with at least three vertices, χs ′ (T, 1) ≤ Δ (T) + 1. Here we generalize this result and show that χs ′ (T, 2) ≤ Δ (T) + 1. Moreover, we show that if for any two vertices u and v with maximum degree d (u, v) ≥ 3, then χs ′ (T, 2) = Δ (T). Also for any tree T with Δ (T) ≥ 3 we prove that χs ′ (T, 3) ≤ 2 Δ... 

    miRNA-encapsulated abiotic materials and biovectors for cutaneous and oral wound healing: Biogenesis, mechanisms, and delivery nanocarriers

    , Article Bioengineering and Translational Medicine ; 2022 ; 23806761 (ISSN) Deka Dey, A ; Yousefiasl, S ; Kumar, A ; Dabbagh Moghaddam, F ; Rahimmanesh, I ; Samandari, M ; Jamwal, S ; Maleki, A ; Mohammadi, A ; Rabiee, N ; Cláudia Paiva-Santos, A ; Tamayol, A ; Sharifi, E ; Makvandi, P ; Sharif University of Technology
    John Wiley and Sons Inc  2022
    Abstract
    MicroRNAs (miRNAs) as therapeutic agents have attracted increasing interest in the past decade owing to their significant effectiveness in treating a wide array of ailments. These polymerases II-derived noncoding RNAs act through post-transcriptional controlling of different proteins and their allied pathways. Like other areas of medicine, researchers have utilized miRNAs for managing acute and chronic wounds. The increase in the number of patients suffering from either under-healing or over-healing wound demonstrates the limited efficacy of the current wound healing strategies and dictates the demands for simpler approaches with greater efficacy. Various miRNA can be designed to induce... 

    i-vector/HMM based text-dependent speaker verification system for RedDots challenge

    , Article 17th Annual Conference of the International Speech Communication Association, INTERSPEECH 2016, 8 September 2016 through 16 September 2016 ; Volume 08-12-September-2016 , 2016 , Pages 440-444 ; 2308457X (ISSN) Zeinali, H ; Sameti, H ; Burget, L ; Cěrnocký, J. H ; Maghsoodi, N ; Sharif University of Technology
    International Speech and Communication Association  2016
    Abstract
    Recently, a new data collection was initiated within the RedDots project in order to evaluate text-dependent and text-prompted speaker recognition technology on data from a wider speaker population and with more realistic noise, channel and phonetic variability. This paper analyses our systems built for RedDots challenge-the effort to collect and compare the initial results on this new evaluation data set obtained at different sites. We use our recently introduced HMM based i-vector approach, where, instead of the traditional GMM, a set of phone specific HMMs is used to collect the sufficient statistics for i-vector extraction. Our systems are trained in a completely phraseindependent way on... 

    Zygomatic bone registration based on a modified student's mixture model method

    , Article 26th National and 4th International Iranian Conference on Biomedical Engineering, ICBME 2019, 27 November 2019 through 28 November 2019 ; 2019 , Pages 88-92 ; 9781728156637 (ISBN) Noori, S. M. R ; Mobaraki, M ; Ahmadian, A ; Bayat, M ; Bahrami, N ; Sharif University of Technology
    Institute of Electrical and Electronics Engineers Inc  2019
    Abstract
    Point Set Registration (PSR) of anatomic parts is used in different fields such as Patient Specific Implant (PSI) design in Computer Assisted Surgery (CAS) procedure. We designed a modified rigid PSR method based on student's-t mixture model. The proposed method is compared with Coherent Point Drift (CPD) registration method. Higher convergence speed and the lower error value are the advantages of the suggested algorithm in compare with CPD. In our method, the number of iterations decreases by about 69%, and the final error improvement was about 7% in comparison with CPD. The robustness of the proposed algorithm makes it beneficial to be used in the procedure of designing PSI in both... 

    ZnFe2O4 nanoparticles as radiosensitizers in radiotherapy of human prostate cancer cells

    , Article Materials Science and Engineering C ; Volume 46 , January , 2015 , Pages 394-399 ; 09284931 (ISSN) Meidanchi, A ; Akhavan, O ; Khoei, S ; Shokri, A. A ; Hajikarimi, Z ; Khansari, N ; Sharif University of Technology
    Elsevier Ltd  2015
    Abstract
    Nanoparticles of high-Z elements exhibit stronger photoelectric effects than soft tissues under gamma irradiation. Hence, they can be used as effective radiosensitizers for increasing the efficiency of current radiotherapy. In this work, superparamagnetic zinc ferrite spinel (ZnFe2O4) nanoparticles were synthesized by a hydrothermal reaction method and used as radiosensitizers in cancer therapy. The magnetic nanoparticles showed fast separation from solutions (e.g., ~ 1 min for 2 mg mL- 1 of the nanoparticles in ethanol) by applying an external magnetic field (~ 1 T). The ZnFe2O4 nanoparticles were applied in an in vitro radiotherapy of lymph node carcinoma of prostate cells (as high... 

    Zn-rich (GaN)1−x(ZnO)x: a biomedical friend?

    , Article New Journal of Chemistry ; Volume 45, Issue 8 , 2021 , Pages 4077-4089 ; 11440546 (ISSN) Bagherzadeh, M ; Rabiee, N ; Fatahi, Y ; Dinarvand, R ; Sharif University of Technology
    Royal Society of Chemistry  2021
    Abstract
    A Zn-Rich (GaN)1−x(ZnO)xnanostructure was synthesized with the assistance of a high-gravity technique in order to reduce the reaction time and temperature. The synthesized inorganic nanomaterial has been applied in both drug and gene delivery systems, and as the first fully inorganic nanomaterial, it was investigated in a comprehensive cellular investigation as well. In order to increase the potential bioavailability, as well as the interactions with the pCRISPR, the nanomaterial was enriched with additional Zn ions. The nanomaterial and the final nanocarrier were characterized at each step before and after any biological analysisviaFESEM, AFM, TEM, FTIR and XRD. The polymer coated... 

    Zinc-stearate-layered hydroxide nanohybrid material as a precursor to produce carbon nanoparticles

    , Article Journal of Alloys and Compounds ; Volume 509, Issue 5 , February , 2011 , Pages 2441-2444 ; 09258388 (ISSN) Ghotbi, M. Y ; Bagheri, N ; Sadrnezhaad, S.K ; Sharif University of Technology
    2011
    Abstract
    Zinc-stearate-layered hydroxide nanohybrid was prepared using stearate anion as an organic guest, and zinc layered hydroxide nitrate, as a layered inorganic host by the ion-exchange method. Powder X-ray diffraction patterns and Fourier transform infrared results indicated that the stearate anion was actually intercalated into the interlayer of zinc layered hydroxide nitrate and confirmed the formation of the host-guest nanohybrid material. Also, surface properties data showed that the intercalation process has changed the porosity for the as-prepared nanohybrid material in comparison with that of the parent material, zinc hydroxide nitrate. The nanohybrid material was heat-treated at 600 °C... 

    Zinc-doped silica/polyaniline core/shell nanoparticles towards corrosion protection epoxy nanocomposite coatings

    , Article Composites Part B: Engineering ; Volume 212 , 2021 ; 13598368 (ISSN) Haddadi, S. A ; Mehmandar, E ; Jabari, H ; Ramazani Saadatabadi, A ; Mohammadkhani, R ; Yan, N ; Arjmand, M ; Sharif University of Technology
    Elsevier Ltd  2021
    Abstract
    Commercial paints and coatings can serve as a protective barrier for metallic substrates in a corrosive environment. A considerable variety of nanostructures can be embedded in a polymeric coating to achieve both barrier and active protection. This research aims to elucidate the role of polyaniline (PANI) as an active polyelectrolyte modifier for the surface modification of mesoporous silica nanoparticles (MSNs) doped with zinc cations (Zn2+). To characterize the samples, we employed different techniques, including field-emission scanning electron microscopy (FE-SEM), transmission electron microscopy (TEM), N2 adsorption-desorption, Fourier transform infrared spectroscopy (FTIR), Raman... 

    Young EFL learners’ attitude towards rall: An observational study focusing on motivation, anxiety, and interaction

    , Article 9th International Conference on Social Robotics, ICSR 2017, 22 November 2017 through 24 November 2017 ; Volume 10652 LNAI , 2017 , Pages 252-261 ; 03029743 (ISSN); 9783319700212 (ISBN) Alemi, M ; Meghdari, A ; Haeri, N. S ; Sharif University of Technology
    Springer Verlag  2017
    Abstract
    In this paper we aimed to explore young Iranian EFL learners’ attitude towards Robot Assisted Language Learning (RALL) in an English language classroom. To this end, 19 preschool children ranging from 3 to 6 years old were randomly assigned to a RALL group which had a robot as an assistant to the teacher. Their attitude towards the robot was video recorded for one month, during ten sessions of their English classroom course. Their overall attitude was examined focusing on the three factors of anxiety, motivation and interaction based on human-robot interaction (HRI) theory. The result of this study showed that children’s motivation increased as a result of interacting with the robot and... 

    You are what you eat: Sequence analysis reveals how plant microRNAs may regulate the human genome

    , Article Computers in Biology and Medicine ; Volume 106 , 2019 , Pages 106-113 ; 00104825 (ISSN) Kashani, B ; Hasani Bidgoli, M ; Motahari, S. A ; Sedaghat, N ; Modarressi, M. H ; Sharif University of Technology
    Elsevier Ltd  2019
    Abstract
    Background: Nutrigenomic has revolutionized our understanding of nutrition. As plants make up a noticeable part of our diet, in the present study we chose microRNAs of edible plants and investigated if they can perfectly match human genes, indicating potential regulatory functionalities. Methods: miRNAs were obtained using the PNRD database. Edible plants were separated and microRNAs in common in at least four of them entered our analysis. Using vmatchPattern, these 64 miRNAs went through four steps of refinement to improve target prediction: Alignment with the whole genome (2581 results), filtered for those in gene regions (1371 results), filtered for exon regions (66 results) and finally... 

    Yield-driven design-time task scheduling techniques for multi-processor system on chips under process variation: A comparative study

    , Article IET Computers and Digital Techniques ; Volume 9, Issue 4 , 2015 , Pages 221-229 ; 17518601 (ISSN) Momtazpour, M ; Assare, O ; Rahmati, N ; Boroumand, A ; Barati, S ; Goudarzi, M ; Sharif University of Technology
    Institution of Engineering and Technology  2015
    Abstract
    Process variation has already emerged as a major concern in design of multi-processor system on chips (MPSoC). In recent years, there have been several attempts to bring variability awareness into the task scheduling process of embedded MPSoCs to improve performance yield. This study attempts to provide a comparative study of the current variation-aware design-time task and communication scheduling techniques that target embedded MPSoCs. To this end, the authors first use a sign-off variability modelling framework to accurately estimate the frequency distribution of MPSoC components. The task scheduling methods are then compared in terms of both the quality of the final solution and the... 

    XPS studies of Cu1-xTlxBa2Ca 2Cu3O10-y superconductor thin films

    , Article Physica C: Superconductivity and its Applications ; Volume 433, Issue 1-2 , 2005 , Pages 21-27 ; 09214534 (ISSN) Khan, N. A ; Khurram, A. A ; Sabeeh, K ; Iraji Zad, A ; Ahadian, M. M ; Sharif University of Technology
    2005
    Abstract
    X-ray photoemission spectroscopy (XPS) of Cu1-xTl xBa2Ca2Cu3O10-δ (Cu1-xTlx-1223) superconductors thin films is studied. These films were prepared by amorphous phase epitaxy method on the SrTiO 3 substrate. This compound has Cu1-xTlxBa 2O4-δ charge reservoir layer and three CuO 2 planes. The atoms in the CuO2 planes have strong covalent bonding, while the some of the atoms in Cu1-xTl xBa2O4-δ charge reservoir, such as oxygen (Oδ) have predominantly secondary bonding and could be removed from the unit cell. The deliberate or inadvertent removal of the oxygen from the unit cell may change the charge state of the constituent atoms in the charge reservoir layer. The charge state of the atoms in... 

    X-ray photoemission studies of Zn doped Cu1-xTlxBa2Ca2Cu 3-yZnyO10-δ (y = 0, 2.65) superconductors

    , Article Physica C: Superconductivity and its Applications ; Volume 453, Issue 1-2 , 2007 , Pages 46-51 ; 09214534 (ISSN) Khan, N. A ; Mumtaz, M ; Ahadian, M. M ; Iraji zad, A ; Sharif University of Technology
    2007
    Abstract
    The X-ray photoemission (XPS) measurements of Cu1-xTlxBa2Ca2 Cu3-yZnyO10-δ (y = 0, 2.65) superconductors have been performed and compared. These studies revealed that the charge state of thallium in the Cu0.5Tl0.5Ba2O4-δ charge reservoir layer in Zn doped samples is Tl1+, while it is a mix of Tl1+ and Tl2+ in Zn free samples. The binding energy of Ba atoms in the Zn doped samples is shifted to higher energy, which when considered along with the presence of Tl1+ suggested that it more efficiently directed the carriers to ZnO2 and CuO2 planes. The evidence of improved inter-plane coupling witnessed in X-ray diffraction is also confirmed by XPS measurements of Ca atoms in the Zn doped samples....