Sharif Digital Repository

Due to significant reduction in fossil fuel sources; several researches have been conducted recently to explore modern sources of renewable energy. One of the major fields in the category of renewable energy harnessing devices is parabolic trough solar collectors (PTC). Several parameters have effect on the overall efficiency of the PTC’s.As the effect of these parameters is coupled to each other, a comprehensive investigation is necessary.In the present study a numerical analysis is performed to examine the efficiency of PTCs via variation of several governing parameters (e.g. wind velocity magnitude, nanoparticles volume fraction, inlet temperature and reflector’s orientation). A detailed... 

Magnetorheological (MR) materials show variations in their rheological properties when subjected to varying magnetic fields. They have quick time response, in the order of milliseconds, and thus are potentially applicable to structures and devices when a tunable system response is required. When integrated with a structural system, they can produce higher variations in the dynamic response of the structure. In this thesis, vibration behavior of laminated-composite beam with MR Fluid is investigated.In most studies, shear strain across the thickness of MR layer has been considered as a constant value which does not precisely describe the actual shear strain field. Shear modulus of MR layer in... 

Obstruction of Left Anterior Descending artery (LAD) due to thrombosis or atherosclerotic plaques is the leading cause of death world–wide. Targeted delivery of drugs through micro- Nano-particles holds noteworthy promise which can make clot busting or the restenosis treatment with minimal toxicity possible. In this work, Fluid-Structure Interaction (FSI) simulations of blood flow through a patient-specific reconstructed geometry of LAD artery have been conducted using a non-Newtonian hematocrit (HCT) dependent model for blood. Based on physiological facts, 25, 45 and 65 percentages of HCT were assumed as acceptable representations of anemic, healthy and diabetic blood conditions,... 

In this study, the performance of an existing Savonius turbine has been improved through designing a curved curtain, the curtain has been placed in front of the rotor. To do so, the main purpose is to increase the net static torque of wind rotor via a newly designed curtain. A new guide vane is designed to prevent negative torque produced by convex surface of wind rotor and increasing wind velocity which is impacted concave side of wind turbine rotor blade. The numerical modeling of flow field is verified by experimental result for wind rotor without straightener. The numerical code verification accomplished at three different angle of rotation which the biggest difference between... 

The application of computational fluid dynamics (CFD) has been growing rapidly in biomedical engineering. The altered hemodynamics inside the blood vessels plays a key role in the development of the arterial disease called atherosclerosis, which is the major cause of human death worldwide. Atherosclerosis is often treated with the stenting procedure to restore the normal blood flow. A stent is a tubular, flexible structure, usually made of metals, which is driven and expanded in the blocked arteries. The presence of non-biological device in the artery causes inflammation or re-growth of atherosclerotic lesions in the treated vessels. Several factors including the design of stents and type of... 

In the present work, trajectory optimization of the Dual-Arm Cam-Lock robot considering kinematic and dynamic redundancy is performed. First, the optimal control problem is solved only considering kinematic redundancy and then is solved considering dynamic redundancy. General form of the dynamic model for the system is developed using Lagrangian relations. Global optimization method is used for redundancy resolution problem. A performance index is defined based on the consumed kinetic energy and is minimized through a desired trajectory using the global optimization method. Formulations of optimal control problem are derived and initial boundary problem is changed to two point boundary value... 

One of the diseases of the central nervous system that are included in the neurodegenerative disorders and its impressive expansion among the people of the world and Iran is an alarming to us, is Alzheimer's disease. Since the cause of the disease has not yet been precisely determined, there is no definite cure for this disease yet. However, an important indicator in the disease is its early diagnosis so that the disease can be controlled and prevented from progressing in the early stages and before the degeneration of neurons. The big challenge that is observed in the diagnosis and effectiveness of drugs in this disease and any type of central nervous system disorder is the existence of the... 

The present study is aimed at the development of a novel approach based on the magnetically improvement of DNA-directed immobilization to prepare a highly efficient sensor for prostate diagnosis. The novelty of this work is in the use of antibody conjugated magnetic nanoparticles via DDI. DNA-modified magnetic nanoparticles are added in solution to capture DNA-conjugated, fluorescently-labeled immunocomplexes formed in solution free of steric constraints. The DDI-based nanoconstructs are then concentrated and immobilized using a magnetic field. Compared to a process in which the immunocomplex directly forms on the sensing surface, the proposed approach provides higher mass transfer and lower... 

The Atomic Energy Organization of Iran (AEOI) has launched a program of low level waste management. This program also includes waste produced at Uranium Conversion Facility (UCF) of Esfahan. The liquid waste, which was generated during the operation of plant and concentrated in lagoon, was characterized for the development of the treatment process. The aim of this study was to recovery of uranium content of liquid waste in the lagoon. The recovery of uranium has the advantage of saving this valuable metal and the avoidance of unacceptable discarding solution to the environment. Uranium may be recovered from an aqueous solution by precipitation, solvent extraction and ion exchange.... 

Prediction of the hydrophobicity of molecules using graph neural networks is one of the advanced methods for analyzing the physicochemical properties of molecules. In this method, the molecular graph structure and its features are used as inputs to neural networks to provide predictions about the hydrophobicity of molecules. This method is currently applied in the pharmaceutical industry, green chemistry, and other research fields. By using this approach, molecules with strong hydrophobic properties can be identified and used in the development of new drugs. Generally, graph neural networks are highly suitable for predicting the properties of molecules and other various applications in the... 

Real-time asynchronous data fusion for high-speed phenomena is an important and challenging task in the sensor networks. Examples of data fusion applications in sensor networks are: managing the traffic of maneuvering airplanes and ground vehicles in airside areas of an airport, traffic management in streets and roads, Driver Assistance Systems, guidance of antiaircraft and antimissile missiles. In all the data fusion applications the estimation of the required variables is necessary.
In this research two methods are introduced for real-time asynchronous data fusion, especially for track-to-track fusion of high-speed phenomena in sensor networks. The effectiveness and usability of these... 

Cartilage is a connective tissue, whose most important role in the body is to create a surface with a low friction coefficient in order to allow bones to slide on each other without direct contact to transfer loads. Articular cartilage is always under a harsh biomechanical environment and lacks blood, lymphatic and nerve vessels. As a result, it limits the capacity of this tissue to improve and restore itself. According to experimental efforts, cartilage cannot be regenerated spontaneously without the support of healthy subchondral bone. In recent years, the implantation of tissue engineering scaffolds has been considered as an effective strategy for the treatment of osteochondral damage.... 

Despite the extensive research conducted so far to treat cancer, this disease is still one of the main causes of death worldwide. The results of recent studies reveal the importance of the tumor microenvironment in the growth, proliferation, and invasion of the primary tumor. Most common models in cancer research, such as 2-dimensional in vitro models and xenografts, do not have sufficient ability to mimic the interaction of tumors with human stromal tissue. Therefore, the implementation of 3-dimensional in vitro models with the ability to replicate tumor microenvironments is essential. In this study, a microfluidic platform has been introduced to create parallel models of the tumor... 

Nerve damage is one of the factors affecting the quality of life of patients. The nervous system does not have the ability to repair large injuries, and autologous transplantation, which is the standard treatment method for nerve injuries, is faced with a shortage of donors and a decrease in the function of the donor site. Tissue engineering hydrogels, due to their similarity to the natural tissue of the stomatal body, are a hope for the repair of nerve tissue. In this research, an injectable, minimally invasive and temperature-sensitive hydrogel based on chitosan-etaglycerophosphate-sodium hydrogen carbonate salt or trisodium phosphate salt containing aligned nanofibers made of gelatin and... 

Articular cartilage is devoid of blood vessels, lymphatics, and nerves which gives it a very limited intrinsic healing and repair capabilities. Being under constant harsh biomechanical environment, makes maintaining the health of articular cartilage a vital principle in having healthy joints. Tissue engineering as a method for regeneration of damaged tissue have attracted a lot of attention. Articular cartilage engineered scaffolds act as a macro scale drug delivery system which in addition to having a good mechanical properties similar to that of cartilage tissue, have to provide a highly porous environment for cell migration and proliferation. The aim of this study is to fabricate a drug... 

In this thesis, reactivity controlled compression ignition (RCCI) combustion fueled by diesel and natural gas is experimentally and numerically investigated. Natural gas as a fuel with low reactivity is injected into the intake manifold, and diesel as a fuel with high reactivity is injected directly into the combustion chamber. One of the main goals of this thesis is to experimentally examine the effect of important parameters on combustion phasing control, operational range extension, and pollutants. Natural gas is one of the important sources of energy in Iran and the world. Using natural gas in internal combustion engines can cause methane to slip into the atmosphere and intensify the...