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    Investigation of Mechanical Properties of Healthy Red Blood Cells using Optical Tweezers

    , M.Sc. Thesis Sharif University of Technology Azadbakht, Ali (Author) ; Seyed Reihani, Nader (Supervisor) ; Moosavi-Movahhedi, Ali Akbar (Co-Advisor)
    Abstract
    Red blood cells (RBC, erythrocytes) are cells with an average diameter of 8 microns, the thickness of 2-3 microns and the volume of 90 fl. The biconcave shape of red blood cells,together with cell membrane flexibility, enables them to pass the capillaries whose diameter is considerably less than 8 micrometers. Mechanical properties of RBC are related to their membrane and cytoskeleton, which consists of spectrin network. Optical tweezers is able to exert very precise forces to erythrocytes using beed as a handle. In this report, we studied mechanical properties of RBC such as elasticity and viscoelasticity using single trap optical tweezers with beads with antibody coated in order to attach... 

    Passive Measurement of Viscoelastic Properties of the Healthy Red Blood Cell by Optical Tweezers

    , M.Sc. Thesis Sharif University of Technology Motaghian, Melika (Author) ; Seyyed Reihani, Nader (Supervisor)
    Abstract
    Blood is one of the most important biological organs. Red blood cell (RBC), as the most abundant cell of blood, plays an important role at life of the living bodies. Unique mechanical properties of RBCs enable them to pass through very narrow vessels. Any abnormality in these mechanical properties will disorder the function of the cell and many diseases affect these properties too. Studying the mechanical properties of RBCs is very importantin that it could result in a disease diagnostic method in a single-cell level. In this thesis we have tried to measure the viscoelastic properties of a single RBC by an optical trap through a passive method. This measurement is made through studying the... 

    Investigating the Effect of Hemoglobin on Viscoelastic Properties of RBC

    , M.Sc. Thesis Sharif University of Technology Felekary, Arash (Author) ; Seyed Reihani, Nader (Supervisor)
    Abstract
    Red blood cells are one of the most important parts of blood and their mechanical properties are so important in some diseases. Red blood cell is mostly consisted of membrane, cell skeleton, and cytoplasm which contains hemoglobin proteins. Studying these properties separately not only could give us pieces of information about cell mechanics, but also reveals a way to predict their behavior after illnesses. Optical tweezers as a tool, which can produce and measure Piconewton to Nanonewton forces, has been interesting in red blood cell parts' studying. In this thesis, at first hemoglobin is taken out gradually by using Saponin (which is enable to make some pores in the membrane) and the... 

    Constitutive Modeling and Numerical Investigation of Damage and Healing Phenomena in Self-healing Polymers at Finite Deformation

    , Ph.D. Dissertation Sharif University of Technology Shahsavari, Hamid (Author) ; Naghdababdi, Reza (Supervisor) ; Sohrabpour, Saeed (Supervisor)
    Abstract
    In this thesis, employing the definition of an effective configuration in the Continuum Damage-Healing Mechanics (CDHM), mechanical responses of elf-healing materials are investigated. Firstly, a constitutive model is proposed to investigate damage and healing phenomena in concrete materials. In order to consider the different behavior of concretes in tension and compression, a spectral decomposition of the stress is utilized. In addition, employing the Clausius-Duhem inequality and considering the irreversible thermodynamics, conjugate forces of the damage and healing are expressed. The Gibbs potential energy is decomposed into three parts; elastic, damage and healing. In the next section,... 

    Empirical and Numerical Modeling of Viscoelastic-Viscoplastic Constitutive Equation for Asphalt Mixture Compaction

    , Ph.D. Dissertation Sharif University of Technology Mohammad Karimi Hosseinabadi, Mohammad (Author) ; Tabatabaee, Nader (Supervisor)
    Abstract
    The numerical simulation of asphalt concrete and pavement has gained considerable attention in recent decades. Information about the response of asphalt pavements during construction and in-service traffic loading is required by pavement specialists for improvement of pavement analysis and design methods. The goal of this study was to propose a constitutive relationship and a numerical modeling method for asphalt concrete compaction in the laboratory and in situ. Asphalt binders exhibit rate-dependent viscoelastic and viscoplastic mechanical behavior in asphalt concrete. The current study examined the viscoelastic and viscoplastic mechanical behavior of asphalt concrete under various loading... 

    Electro-Rheological Investigation of Flows and Transport Phenomena in Micro-Nanofluidic Systems

    , Ph.D. Dissertation Sharif University of Technology Reshadi, Milad (Author) ; Saeedi, Mohammad Hassan (Supervisor)
    Abstract
    In recent decades, significant advances have been made in the manufacturing of micro/-nanofluidic equipment that can reduce the cost of conducting electrochemical experiments and increase the accuracy, speed, and control of these experiments. In this regard, by installing micro/nano-networks on laboratories on a chip, the above objectives have been made possible. Due to the increase in surface-to-volume with decreasing of size of devices, important surface phenomena such as electrokinetics may reach a special place to control the micro/nanoflow. On the other hand, since each of the materials used in the construction of the above equipment reveals a special property in contact with different... 

    Aeroelastic Analysis of Sandwich wing With Fractional Viscoelastic Core

    , M.Sc. Thesis Sharif University of Technology Ebrahimi, Hossein (Author) ; Haddadpour, Hassan (Supervisor)
    Abstract
    In this research, the effect of application of viscoelastic material with fractional derivatives pattern in aeroelastic stability analysis for a sandwich wing, has been examined. In order to study the wing’s aeroelastic behavior and the effect of inner layer on aeroelastic instability boundaries (fluttering), the wing is modeled as a cantilever sandwich beam with a fractional viscoelastic core. The Wagner approximation is used for applying the unstable aeroelastic loads. To obtain the characteristics and behaviors of the structure some assumptions including non-classical effects, are considered. These non-classical effects are the inner layer shear stress, the axial movements, the wing’s...