Sharif Digital Repository

In this paper we analyse two variants of SIMON family of light-weight block ciphers against variants of linear cryptanalysis and present the best linear cryptanalytic results on these variants of reducedround SIMON to date. We propose a time-memory trade-off method that finds differential/ linear trails for any permutation allowing low Hamming weight differential/ linear trails. Our method combines low Hamming weight trails found by the correlation matrix representing the target permutation with heavy Hamming weight trails found using a Mixed Integer Programming model representing the target differential/linear trail. Our method enables us to find a 17-round linear approximation for SIMON-48... 

In this paper, we consider a different strategy for Broadcast-Relay- Networks (BRN) with two relays. There are a transmitter, two relays and two receivers in this network. The message of the transmitter intended to the receivers, has both common and private parts. The relays partially cooperate with each other and with the transmitter to send the common part of the message. The private parts of the message are sent to the corresponding receiver by the cooperation of the corresponding relay. We propose an achievable rate region for this network. In the proof, we take advantage of regular encoding/sliding window decoding at relays and simultaneous backward decoding analysis at receivers. The... 

SIMON is a family of 10 lightweight block ciphers published by Beaulieu et al. from the United States National Security Agency (NSA). A cipher in this family with K-bit key and N-bit block is called SIMONN/K. We present several linear characteristics for reduced-round SIMON32/64 that can be used for a key-recovery attack and extend them further to attack other variants of SIMON. Moreover, we provide results of key recovery analysis using several impossible differential characteristics starting from 14 out of 32 rounds for SIMON32/64 to 22 out of 72 rounds for SIMON128/256. In some cases the presented observations do not directly yield an attack, but provide a basis for further analysis for... 

A new scenario for simultaneously generating a secret key and two private keys among three Terminals in the presence of an external eavesdropper is considered. Terminals 1, 2 and 3 intend to share a common secret key concealed from the external eavesdropper (Terminal 4) and simultaneously, each of Terminals 1 and 2 intends to share a private key with Terminal 3 while keeping it concealed from each other and from Terminal 4. All four Terminals observe i.i.d. outputs of correlated sources and there is a public channel from Terminal 3 to Terminals 1 and 2. An inner bound of the secret key-private keys capacity region is derived and the single letter capacity regions are obtained for some... 

In this paper, we introduce a generalization of the Multiple-Access-Relay- Channel (MARC) called Multiple-Access-Relay-Network (MARN). In the proposed network, there are many transmitters, many relays and one receiver. The MARC model was first introduced by Kramer and consists of many transmitters, one receiver and only one relay.We also define semi-deterministic MARN, in which the output of the link between each transmitter and each relay is a deterministic function of the transmitter's input. We first obtain an achievable rate region for MARN by considering Partial Decode-and-Forward (PDF) strategy at the relays. Then we show that in semi-deterministic MARN, the proposed achievable rate... 

A source model for secret key generation between terminals is considered. Two users, namely users 1 and 2, at one side communicate with another user, namely user 3, at the other side via public channels where three users can observe i.i.d outputs of correlated sources. Each of users 1 and 2 intends to share a secret key with user 3 where user 1 acts as a wiretapper for user 2 and vice versa. In this model, two situations are considered: communication from users 1 and 2 to user 3 (forward key strategy) and from user 3 to users 1 and 2 (backward key strategy). This model is motivated by wireless communications when considering user 3 as a base station and users 1 and 2 as network users. In... 

Advanced nanomaterials such as carbon nanotubes (CNTs) display unprecedented properties such as strength, electrical conductance, thermal stability, and intriguing optical properties. These properties of CNT allow construction of small microfluidic devices leading to miniaturization of analyses previously conducted on a laboratory bench. With dimensions of only millimeters to a few square centimeters, these devices are called lab-on-a-chip (LOC). A LOC device requires a multidisciplinary contribution from different fields and offers automation, portability, and high-throughput screening along with a significant reduction in reagent consumption. Today, CNT can play a vital role in many parts... 

Neural tissue engineering aims at developing novel approaches for the treatment of diseases of the nervous system, by providing a permissive environment for the growth and differentiation of neural cells. Three-dimensional (3D) cell culture systems provide a closer biomimetic environment, and promote better cell differentiation and improved cell function, than could be achieved by conventional two-dimensional (2D) culture systems. With the recent advances in the discovery and introduction of different types of stem cells for tissue engineering, microfluidic platforms have provided an improved microenvironment for the 3D-culture of stem cells. Microfluidic systems can provide more precise... 

We study learning algorithms when there is a mismatch between the distributions of the training and test datasets of a learning algorithm. The effect of this mismatch on the generalization error and model misspecification are quantified. Moreover, we provide a connection between the generalization error and the rate-distortion theory, which allows one to utilize bounds from the rate-distortion theory to derive new bounds on the generalization error and vice versa. In particular, the rate-distortion-based bound strictly improves over the earlier bound by Xu and Raginsky even when there is no mismatch. We also discuss how 'auxiliary loss functions' can be utilized to obtain upper bounds on the... 

According to the latest report from the World Health Organization, an estimated 265,000 deaths still occur every year as a direct result of burn injuries. A widespread range of these deaths induced by burn wound happens in low- and middle-income countries, where survivors face a lifetime of morbidity. Most of the deaths occur due to infections when a high percentage of the external regions of the body area is affected. Microbial nutrient availability, skin barrier disruption, and vascular supply destruction in burn injuries as well as systemic immunosuppression are important parameters that cause burns to be susceptible to infections. Topical antimicrobials and dressings are generally... 

Cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) and programmed cell death protein 1 (PD-1), two clinically relevant targets for the immunotherapy of cancer, are negative regulators of T-cell activation and migration. Optimizing the therapeutic response to CTLA-4 and PD-1 blockade calls for a more comprehensive insight into the coordinated function of these immune regulators. Mathematical modeling can be used to elucidate nonlinear tumor–immune interactions and highlight the underlying mechanisms to tackle the problem. Here, we investigated and statistically characterized the dynamics of T-cell migration as a measure of the functional response to these pathways. We used a previously... 

Colloidal inorganic nanoparticles have wide applications in the detection of analytes and in biological assays. A large number of these assays rely on the ability of gold nanoparticles (AuNPs, in the 20 nm diameter size range) to undergo a color change from red to blue upon aggregation. AuNP assays can be based on cross-linking, non-cross linking or unmodified charge-based aggregation. Nucleic acid-based probes, monoclonal antibodies, and molecular-affinity agents can be attached by covalent or non-covalent means. Surface plasmon resonance and SERS techniques can be utilized. Silver NPs also have attractive optical properties (higher extinction coefficient). Combinations of AuNPs and AgNPs... 

Introduction: Carbon nanotubes (CNT) have recently been studied as novel and versatile drug and gene delivery vehicles. When CNT are suitably functionalized, they can interact with various cell types and are taken up by endocytosis.Areas covered: Anti-cancer drugs cisplatin and doxorubicin have been delivered by CNT, as well as methotrexate, taxol and gemcitabine. The delivery of the antifungal compound amphotericin B and the oral administration of erythropoietin have both been assisted using CNT. Frequently, targeting moieties such as folic acid, epidermal growth factor or various antibodies are attached to the CNT-drug nanovehicle. Different kinds of functionalization (e.g., polycations)... 

In this paper, we introduce discrete memoryless Interference Channel (IFC) with two relays as two interfering transmitter-receiver pairs that are aided by two relays. We propose two different coding strategies for this channel. In the first strategy, we assume that each relay tries to mainly help one of the transmitter-receiver pairs through signal relaying and interference cancellation, while in the second strategy we assume that each relay tries to help both transmitter-receiver pairs. In our coding schemes, we employ rate-splitting, generalized block Markov coding, superposition coding and Gel'fand-Pinsker binning to cancel parts of the interference known to be experienced at the... 

Introduction: It is 23 years since carbon allotrope known as carbon nanotubes (CNT) was discovered by Iijima, who described them as "rolled graphite sheets inserted into each other". Since then, CNTs have been studied in nanoelectronic devices. However, CNTs also possess the versatility to act as drug- and gene-delivery vehicles.Areas covered: This review covers the synthesis, purification and functionalization of CNTs. Arc discharge, laser ablation and chemical vapor deposition are the principle synthesis methods. Non-covalent functionalization relies on attachment of biomolecules by coating the CNT with surfactants, synthetic polymers and biopolymers. Covalent functionalization often... 

New achievements in the realm of nanoscience and innovative techniques of nanomedicine have moved micro/nanoparticles (MNPs) to the point of becoming actually useful for practical applications in the near future. Various differences between the extracellular and intracellular environments of cancerous and normal cells and the particular characteristics of tumors such as physicochemical properties, neovasculature, elasticity, surface electrical charge, and pH have motivated the design and fabrication of inventive "smart" MNPs for stimulus-responsive controlled drug release. These novel MNPs can be tailored to be responsive to pH variations, redox potential, enzymatic activation, thermal... 

Background: Oral rehydration solution (ORS) is a form of oral rehydration therapy (ORT) for diarrhoea that has the potential to drastically reduce child mortality; yet, according to UNICEF estimates, less than half of children younger than 5 years with diarrhoea in low-income and middle-income countries (LMICs) received ORS in 2016. A variety of recommended home fluids (RHF) exist as alternative forms of ORT; however, it is unclear whether RHF prevent child mortality. Previous studies have shown considerable variation between countries in ORS and RHF use, but subnational variation is unknown. This study aims to produce high-resolution geospatial estimates of relative and absolute coverage of...