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Cancer Cell Separation Using Spiral Microchannel
, M.Sc. Thesis Sharif University of Technology ; Saidi, Mohmmad Said (Supervisor) ; Firoozbakhsh, Keykhosrow (Supervisor)
Abstract
Particle separation has a variety of applications in biology, chemistry and industry. Among them, circulating tumor cells (CTCs) separation has drawn significant attention to itself due to its high impact on both cancer diagnosis and therapeutics. In recent years, there has been growing interest in using inertial microfluidics to separate micro/nano particles based on their sizes. This technique offers label-free, high throughput, and efficient separation and can be easily fabricated. However, further improvements are needed for potential clinical applications. In this study, a novel inertial separation technique using spiral microchannel with stair-like cross section is introduced. The...
Spiral microchannel with stair-like cross section for size-based particle separation
, Article Microfluidics and Nanofluidics ; Volume 21, Issue 7 , 2017 ; 16134982 (ISSN) ; Kowsari Esfahan, R ; Saidi, M. S ; Firoozbakhsh, K ; Sharif University of Technology
Springer Verlag
2017
Abstract
Particle separation has a variety of applications in biology, chemistry and industry. Among them, circulating tumor cells (CTCs) separation has drawn significant attention to itself due to its high impact on both cancer diagnosis and therapeutics. In recent years, there has been growing interest in using inertial microfluidics to separate micro/nano particles based on their sizes. This technique offers label-free, high-throughput and efficient separation and can be easily fabricated. However, further improvements are needed for potential clinical applications. In this study, a novel inertial separation technique using spiral microchannel having stair-like cross section is introduced. The...
Study the Interaction between Cytoskleton and Cell Membrane
, M.Sc. Thesis Sharif University of Technology ; Nejat Pishkenari, Hossein (Supervisor) ; Salarieh, Hassasn (Supervisor)
Abstract
In this project the main aim is to model the interaction between the cytoskeleton and cell membrane. In order to model the membrane and cytoskeleton it is used a discrete model, which contains several beads. For modeling the interaction between the beads it is used different kinds of energies. It is used four potentials in a 2D model for modeling the interaction between the membrane beads and it is used SSLJ potential in order to model the interaction between the cytoskeleton and cell membrane. Furthermore, this potential is used to model the interaction between the cytoskeleton filaments. Due to this potential, the cytoskeleton filaments can cross each other in the 2D model. For modeling...
Thermodynamic modeling and optimization of cogeneration heat and power system using Evolutionary algorithm (Genetic Algorithm)
, Article Proceedings of the ASME Turbo Expo, 14 June 2010 through 18 June 2010 ; Volume 3 , 2010 , Pages 745-752 ; 9780791843987 (ISBN) ; Karrabi, H ; Ghadami, S ; Barzegar, H ; Rasoulipour, S ; Kebriyaie, M ; Sharif University of Technology
2010
Abstract
A gas-turbine cogeneration system with a regenerative air preheater and a single-pressure exhaust gas boiler serves as an example for application of CHP Plant. This CHP plant which can provide 30 MW of electric power and 14kg/s saturated steam at 20 bars. The plant is comprised of a gas turbine, air compressor, combustion chamber, and air pre-heater as well as a heat recovery steam generator (HRSG). The design Parameters of the plant, were chosen as: compressor pressure ratio (rc), compressor isentropic efficiency (ηac), gas turbine isentropic efficiency (ηgt), combustion chamber inlet temperature (T3), and turbine inlet temperature (T4). In order to optimally find the design parameters a...
Optimization of Multilateral Wells
, M.Sc. Thesis Sharif University of Technology ; Taghizadeh Manzari, Mehrdad (Supervisor) ; Kazemzadeh Hannani, Siamak (Supervisor) ; Seif, Mohammad Saeed (Supervisor)
Abstract
Multilateral wells are relatively new alternatives in field development and because they can increase the productivity per well and reduce the cost of field development, they are rapidly replacing old methods. In order to predict the performance of well, three methods are usually used: Analytical methods which use closed-forms models, semi-analytical methods which entails line-source model and numerical methods which is based on techniques such as finite volume or finite difference. In this thesis, line-source model is extended from two dimensional forms to three dimensional forms in order to be used to optimize the path of multilateral wells. Optimization entails direct optimization...