Sharif Digital Repository

Acinar region consists of ~ 33 million airways and provides low resistance against the gas exchange with blood. A three-dimensional anatomically accurate model of pulmonary acinus is useful for simulation of fluid distribution, gas exchange, particle deposition, drug delivery, and detection of structural abnormalities in the lungs. In this study, the stochastic parametric Lindenmayer system has been used to generate the respiratory airways filling a given space. This model takes into account the mechanical properties and details of human acinus which can accurately predict the gas distribution throughout the lungs for the first time. The procedure of finding the dimensions and orientations... 

Gas exchange, particle deposition, and drug delivery in the human lungs depend on the structure of the human bronchial tree. The conducting airways occupy the main portion of the human lungs and transport air from outside into pulmonary acini where the O2–CO2 exchange with blood occurs. Therefore, the generation of three-dimensional accurate structure of the conducting airways is required for simulation of the transport phenomena in the human respiratory system. The present study proposes an intelligent method for generation of conducting airways based on stochastic parametric Lindenmayer system (L-system). The conducting airways grow into the bronchopulmonary segments simultaneously using... 

The bronchial tree plays a main role in the human respiratory system because the air distribution throughout the lungs and gas exchange with blood occur in the airways whose dimensions vary from several centimeters to micrometers. Organization of about 60,000 conducting airways and 33 million respiratory airways in a limited space results in a complex structure. Due to this inherent complexity and a high number of airways, using target-oriented dimensional reduction is inevitable. In addition, there is no general reduced-order model for various types of problems. This necessitates coming up with an appropriate model from a variety of different reduced-order models to solve the desired... 

The curve of exhaled inert gas concentration against exhaled volume is called gas washout curve. The slope at the end part of gas washout curve (Sn) is a measure of structural abnormalities. Sn depends on the spatial concentration distribution and dynamic of gas washout, which depends on several mechanisms including asymmetry of airways, nonhomogeneous ventilation, sequential emptying, and gas exchange with blood. Due to a large number of airways in human lungs, using simplified models is inevitable. On the other hand, these simplified models cannot capture some of the mentioned mechanisms and subsequently were not able to predict experimental trend of change in Sn with breath number in... 

Acinar region consists of ~ 33 million airways and provides low resistance against the gas exchange with blood. A three-dimensional anatomically accurate model of pulmonary acinus is useful for simulation of fluid distribution, gas exchange, particle deposition, drug delivery, and detection of structural abnormalities in the lungs. In this study, the stochastic parametric Lindenmayer system has been used to generate the respiratory airways filling a given space. This model takes into account the mechanical properties and details of human acinus which can accurately predict the gas distribution throughout the lungs for the first time. The procedure of finding the dimensions and orientations... 

Gas exchange, particle deposition, and drug delivery in the human lungs depend on the structure of the human bronchial tree. The conducting airways occupy the main portion of the human lungs and transport air from outside into pulmonary acini where the O2–CO2 exchange with blood occurs. Therefore, the generation of three-dimensional accurate structure of the conducting airways is required for simulation of the transport phenomena in the human respiratory system. The present study proposes an intelligent method for generation of conducting airways based on stochastic parametric Lindenmayer system (L-system). The conducting airways grow into the bronchopulmonary segments simultaneously using... 

In this paper, we study transmission of a memoryless Laplacian source over three types of channels: additive white Laplacian noise (AWLN), additive white Gaussian noise (AWGN), and slow flat-fading Rayleigh channels under both bandwidth compression and bandwidth expansion. For this purpose, we analyze two well-known hybrid digital-analog (HDA) joint source-channel coding schemes for bandwidth compression and one for bandwidth expansion. Then we obtain achievable (absolute-error) distortion regions of the HDA schemes for the matched signal-to-noise ratio (SNR) case as well as the mismatched SNR scenario. Using numerical examples, it is shown that these schemes can achieve a distortion very... 

In this study; a Sugeno type ANFI model which describes the relationship between the bio surfactant concentration as a model output and the critical medium components as its inputs has been constructed. The critical medium components are glucose, urea,SrCl2 and MgSo4 .The experimental data for training and testing capability of the model obtained by a statistical experimental design which have been captured from literatures. Six generalized bell shaped membership function have been selected for each of input variables and based on the training data ANFI model has been trained using the hybrid learning algorithm. The yielded biosurfactant concentration values from the model prediction shows... 

In this investigation, application of the least square support vector machine (LSSVM) for modeling of the electrical resistivity of the magnetic Zn-Mn-S nanocrystalline semiconductor films has been described. The model has been trained based on the experimental data obtained from a published work by Sreekantha Reddy et al. The model inputs are temperature and variations in the concentrations of Zn, Mn. The results indicate that LSSVM is able to be used for accurate prediction of the electrical resistivity of the Zn-Mn-S nanocrystalline semiconductor films  

In order to better understand the mechanical properties of biological cells, characterization and investigation of their material behavior is necessary. In this paper hyperelastic Neo-Hookean material is used to characterize the mechanicalproperties of mouse oocyte cell. It has been assumed that the cell behavior is continues, isotropic, nonlinear and homogenous material. Then, by matching the experimental data with finite element (FE) simulation result and using the LevenbergâMarquardt optimization algorithm, the nonlinear hyperelastic model parameters have been extracted. Experimental data of mouse oocyte captured from literatures. Advantage of the developed model is that it can be used to... 

Analysis and investigation of the relation between different parts of biological cells such as biomembrane, cytoplasm and nucleus can help to better understand their behaviors and material properties. In this paper, first, the whole elastic properties of mouse oocyte and embryo cells have been computed by inverse finite element and Levenberg-Marquardt optimization algorithm and second, using the derived mechanical properties and the mechanical properties of its bio membrane from the literature, the mechanical properties of its cytoplasm has been characterized. It has been assumed that the cell behavior is as continues, isotropic, nonlinear and homogenous material for modeling. Matching the... 

Nano-micro grippers are able to pick-transport-place the micro or nanometer -sized materials, such as manipulation of biological cells or DNA molecules in a liquid medium. This paper proposes a novel monolithic nano-micro gripper structure with two axis piezoresistive force sensor which its resolution is under nanoNewton. The results of the study have been obtained by the simulation of the proposed gripper structure in Matlab software. Motion of the gripper arm is produced by a voice coil actuator. The behavior of the cell has been derived using the assumptions in the literatures. Moreover, two simple PID controllers, one for control of the gripper motion and another for control of the force... 

Evaluation of the reaction force on a tool which is used for exertion of force on biomaterials such as biological cells or soft tissues has applications in virtual reality based medical simulators or haptic tools. In this study, two least square based support vector machine (SVM) models have been constructed to predict the indentation or reaction force on mouse oocyte and embryo cells in cell injection experiment. Inputs of these two models are geometrical parameters of indented cell, namely dimple radius (a), dimple depth (w) and radius of the semicircular curve (R). Experimental data for calibration and prediction of the models have been captured from literatures. The performance of the...