Sharif Digital Repository

Nowadays, due to the advancement in manufacturing technology and increasing use of information technology in the services and industries, most of production proccess consist of complex and high-dimensional data. These processes include multivariate processes, complex profiles and multistage processes. In some quality control applications, processes consist of multiple components, stations or stages to finish the final product or service which are called multistage processes. In addition, some quality characteristics in each stage can be represented by a relationship between a response variable and one or more explanatory variables which is named as profile. In this research, a general model... 

Drug delivery systems (DDS), which, are sensitive to tumor medium have high importance. one of the most important problem of current treatment of cancer is damage of the normal tissue, which, it is expected to solve by smart drug delivery systems. In such cases, one or more features of cancer medium cause to release of the drug. One of features of cancer medium is high concentration of reactive oxygen species and hydrogen peroxide in the most common between them. The purpose of this study is to build a drug delivery system, which it is sensitive to hydrogen peroxide. This carrier has 4 main parts. The first part is anti-cancer drug, which, it is located in the carrier. Second part is... 

Single-cell RNA-sequencing has opened opportunities to unlock the cell transcriptome at cellular-level resolution and investigate cell population structures and cell-type-specific gene expression patterns. Previously, we were only able to perform bulk RNA sequencing regardless of the cell type composition of cell populations. Now, with the advancements in sequencing technologies, it is possible to extract cell-level and cell-type-specific sequences, related to each type of cell separately and in a scalable and high-throughput manner. For such large studies, logistical constraints inevitably dictate that data be generated separately i.e., at different times and with different operators.... 

As the core of this thesis, we express the relation between optimal transportation and convex geometry especially the variational approach to solve Alexandrov problem, which leads to a geometric interpretation to adversarial models and propose a novel framework for these models. Along the way, we peruse generative adversarial networks from optimal transportation view and show that generator calculates the transportation map and the discriminator computes Wasserestein distance, which is equivalent to Kantorovich potential. By using optimal mass transportation theory and choosing an especial cost function c, we see that the generator and discriminator are equivalent. Therefore, once the... 

Nowadays environment is under demolition from various aspects which the chemical pollution can be mentioned as an example. The aim of this research is to eliminate the 4nitrophenol as a pollutant through catalysis process. In the current study, to synthesis of the gold nanoparticles on the modified molybdenum de sulfide with nickel (MNi/MoS2 (M=Au, Pt)) an effective method was utilized. In the following, the structural and morphological features of the synthesized nano composites (MNi/MoS2) via different microscopic and macroscopic methods be identified. Obtained results from identification of the materials demonstrated the expected catalysts were synthesized successfully. Finally, to... 

The basis of this research is the use of millimeter wave frequency band, due to its unique features for standoff imaging. The millimeter wave standoff system used in this thesis faces challenges such as sensitivity to change of angle, separation of the object from the background and the inability of the system to accurately detect the edges of the object, that the purpose of defining this project is to provide solutions and their feasibility with imaging system to minimize these challenges. For this purpose, first the imaging process of the system is generally simulated by two methods of physical optics/physical theory of diffraction and equivalence method and then for different conditions... 

Phospholipid membranes and vesicles play important roles in the cellular functioning, otein signaling and material transport inside cells. Protein-embedded vesiclesare also used for targeted drug delivery. In this thesis, we use molecular dynamicsmethods and study (i) the formation of vesicles from flat lipid bilayers (ii) the mechanicalproperties of vesicles under compressive forces (iii) the shape variations ofvesicles with and without transmembrane proteins (iv) protein clustering.We grow our vesicles from lipid bilayers, which may contain proteins with differentconcentrations. We start with a random initial distribution of proteins that allowsus to monitor the clustering and... 

Wireless sensor network is composed of a large number of sensor nodes which are densely deployed to monitor the environment and collect information from physical events. There are different modelsfor sending collected data to users; one of them is query-driven models, in which according to user interest and via declarative queries collected data is delivered. Wireless sensor networks are energy constrained; regarding this issue, it is necessary to have an energy efficient design. Data aggregation or in network processing is one existing solution to reduce energy consumption. Data correlation or redundancy is also can be used with this method to save energy even more. In this thesis, an... 

Hydrogen bond is a type of molecular bond which occurs between hydrogen and a highly electronegative atom (usually F, N and O) and results in special properties.Alkyl phosphonic acids and their derivatives have several applications as pesticides, antibiotics and anti-viruses. Furthermore, some chemicals in human nervous system hydrolyze to alkyl phosphonates and finally to methyl phosphonic acid. Linear alkyl phosphonic acids and their saults have both organic nonpolar hydrophobic groups and inorganic hydrophilic groups and used as surfactants.Different substituents can affect the acidity of alkyl phosphonic acids. Investigation have shown that hydroxyl functional group can increase the... 

The main object of this thesis is preparation and investigation of polyolophine/graphene oxide nanocomposites by using bi-supported Ziegler-Natta catalytic system and in-situ polymerization. Magnesium ethoxide and graphene oxide were used as supports of catalyst. TiCl4 was accompanied by triisobutyl aluminum (tibia) and diisobutyl phthalate (DIBP) as an electron donor constituting Ziegler-Natta catalytic system. Preparation of catalyst and polymerization were taken place in slurry phase under the argon atmosphere. At the beginning of the polymerization experiment, several type of nanocomposites were made under various conditions (such as different Al/Ti molar ratio) to find optimum condition... 

The change in distribution and consumption of electrical energy has increased attention to smart grid. The smart grid is expected to enhance efficiency and reliability of power systems. Along with the important features, cyber security emerges to be a critical issue because electronic devices are inter-connected via communication and computer networks throughout power facilities. In recent years, cybersecurity of intelligent electronic devices (IEDs) in the substations has been recognized as a critical issue for the electrical smart grid. These devices provide remote accesses to perform the given control commands. Taking this into account, some concern has arised about cyber threats result... 

Application of evolutionary algorithms in software testing, called evolutionary testing, has been an area of interest for many researchers. Automatic generation of test cases is the main purpose of evolutionary testing. In recent years lots of tools for test case generation in structured and object oriented softwares has been developed using different evolutionary algorithms. All of theses tools targeted unit test case generation and high code coverage of class under test. In this thesis we propose an approach for generation of integration test cases in object oriented softwares. We use bottom-up integration approach for generation of test cases by applying the solutions presented for...