Sharif Digital Repository

In the present study, first, Fe3O4nanoparticles were functionalized using glutaric acid and then composited with CQDs. Doxorubicin (DOX) drug was loaded to evaluate the performance of the nanocomposite for targeted drug delivery applications. The XRD pattern confirmed the presence of characteristic peaks of CQDs and Fe3O4. In the FTIR spectrum, the presence of carboxyl functional groups on Fe3O4/CQDs was observed; DOX (positive charge) is loaded onto Fe3O4/CQDs (negative charge) by electrostatic absorption. FESEM and AFM images showed that the particle sizes of Fe3O4and CQDs were 23-75 and 1-3 nm, respectively. The hysteresis curves showed superparamagnetic properties for Fe3O4and Fe3O4/CQDs... 

Free Content Selective synthesis of conjugated enynes from α-arylalkynols using LiCl-Acidic Al2O3 under solvent-free conditions  

7H-benzimidazo[2,1-a]benz[de]isoquinolin-7-one compounds were prepared in a selective manner by reaction between o-phenylenediamines and appropriate 1,8-naphthalenedicarboxylic anhydrides using acidic alumina under microwave irradiation  

Background: Chinese hamster ovary (CHO) cell line is considered as the most common cell line in the biopharmaceutical industry because of its capability in performing efficient post-translational modifications and producing the recombinant proteins, which are similar to natural human proteins. The optimization of the upstream process via different feed strategies has a great impact on the target molecule expression and yield. Methods: To determine and understand the molecular events beneath the feed effects on the CHO cell, a label-free quantitative proteomic analysis was applied. The proteome changes followed by the addition of a designed amino acid feed to the monoclonal antibody producing... 

Classical sampling theorem states that by using an anti-aliased low-pass filter at the Nyquist rate, one can transmit and retrieve the filtered signal. This approach, which has been used for decades in signal processing, is not good for high quality speech, image and video signals where the actual signals are not low-pass but rather sparse. The traditional sampling theorems do not work for sparse signals. Modern approach, developed by statisticians at Stanford (Donoho and Candes), give some lower bounds for the minimum sampling rate such that a sparse signal can be retrieved with high probability. However, their approach, using a sampling matrix called compressive matrix, has certain... 

(Liquid + liquid) equilibrium (LLE) data for the ternary systems (heptane + toluene + 1-ethyl-3-methylpyridinium ethylsulfate) and (heptane + benzene + 1-ethyl-3-methylpyridinium ethylsulfate) were measured at T = 298.15 K and atmospheric pressure. The selectivity and aromatic distribution coefficients, calculated from the equilibrium data, were used to determine if this ionic liquid can be used as a potential extracting solvent for the separation of aromatic compounds from heptane. The consistency of tie-line data was ascertained by applying the Othmer-Tobias and Hand equations  

Drug loading in electrospun nanofibers has gained a lot of attention as a novel method for direct drug release in an injury site to accelerate wound healing. The present study deals with the fabrication of silk fibroin (SF)-chitosan (CS)-silver (Ag)-curcumin (CUR) nanofibers using the electrospinning method, which facilitates the pH-responsive release of CUR, accelerates wound healing, and improves mechanical properties. Response surface methodology (RSM) was used to investigate the effect of the solution parameters on the nanofiber diameter and morphology. The nanofibers were characterized via Fourier Transform Infrared Spectroscopy (FTIR), X-ray Diffraction (XRD), Scanning Electron... 

An eight-step synthetic strategy was followed to prepare a series of novel azobenzene-containing methacrylate monomers bearing spiroacetal-norbornene moiety and methylene spacers. Thus, the adduct 2, obtained from cyclopentadiene and acrolein, was converted to 1,3-diol 3. The diol was acetalized with nitrobenzaldehyde 4 under microwave irradiation to obtain nitro compound 5 that was then reduced to amino compound 6. Diazonium salt of 6 was coupled with phenol to produce phenolic compound 7 which was then reacted with n-dibromoalkanes (n=2, 4, 6, 8, 10) to yield bromo compounds 9a–e. Nucleophilic substitution reaction of the bromo compounds with lithium methacrylate produced the methacrylic...