Sharif Digital Repository

It is well understood that patients with different diseases may have a variety of specific proteins (e.g., type, amount, and configuration) in their plasmas. When nanoparticles (NPs) are exposed to these plasmas, the resulting coronas may incorporate some of the disease-specific proteins. Using gold (Au) NPs with different surface properties and corona composition, we have developed a technology for the discrimination and detection of two neurodegenerative diseases, Alzheimer's disease (AD) and multiple sclerosis (MS). Applying a variety of techniques, including UV-visible spectra, colorimetric response analyses and liquid chromatography-tandem mass spectrometry, we found the corona-NP... 

Our purpose was to determine whether perfusion MR imaging can be used for malignancy determination of tumors. Relative cerebral blood flow (rCBF) is a commonly used perfusion magnetic resonance imaging (MRI) technique for the evaluation of malignancy. The goal of our study was to determine the usefulness of this parameter in malignancy determination of tumors using Independent Component Analysis (ICA)  

Context. Trans-Neptunian objects (TNOs) and Centaurs are remnants of our planetary system formation, and their physical properties have invaluable information for evolutionary theories. Stellar occultation is a ground-based method for studying these distant small bodies and has presented exciting results. These observations can provide precise profiles of the involved body, allowing an accurate determination of its size and shape. Aims. The goal is to show that even single-chord detections of TNOs allow us to measure their milliarcsecond astrometric positions in the reference frame of the Gaia second data release (DR2). Accurate ephemerides can then be generated, allowing predictions of... 

The placement of the Last Level Cache (LLC) banks in the GPU on-chip network can significantly affect the performance of memory-intensive workloads. In this paper, we attempt to offer a placement methodology for the LLC banks to maximize the performance of the on-chip network connecting the LLC banks to the streaming multiprocessors in GPUs. We argue that an efficient placement needs to be derived based on a novel metric that considers the latency hiding capability of the GPUs through thread level parallelism. To this end, we propose a throughput aware metric, called Effective Latency Impact (ELI). Moreover, we define an optimization problem to formulate our placement approach based on the... 

Human infertility is a multifactorial disease that affects 8%–12% of reproductive-aged couples worldwide. However, the genetic causes of human infertility are still poorly understood. Synaptonemal complex (SC) is a conserved tripartite structure that holds homologous chromosomes together and plays an indispensable role in the meiotic progression. Here, we identified three homozygous mutations in the SC coding gene C14orf39/SIX6OS1 in infertile individuals from different ethnic populations by whole-exome sequencing (WES). These mutations include a frameshift mutation (c.204_205del [p.His68Glnfs∗2]) from a consanguineous Pakistani family with two males suffering from non-obstructive... 

The Low-Frequency Array (LOFAR) is under construction in the Netherlands and in several surrounding European countries. In this contribution, we describe the layout and design of the telescope, with particular emphasis on the imaging characteristics of the array when used in its 'standard imaging' mode. After briefly reviewing the calibration and imaging software used for LOFAR image processing, we show some recent results from the ongoing imaging commissioning efforts. We conclude by summarizing future prospects for the use of LOFAR in observing the little-explored low-frequency Universe