Sharif Digital Repository

A triple antibiotic mixture (ciprofloxacin, metronidazole, and minocycline) has been used for dental root canal medicaments in pulp regeneration therapy. However, tooth discolorations, cervical root fractures, and inadequate pulp-dentin formation have been reported due to the triple antibiotic regimen. Therefore, antibiotic containing scaffold has been developed to minimize the clinical limitations and maximize a natural healing process in root canal infections. The ideal controlled release drug device should have the following characteristics. It should not degrade inside the root canal and it should be easily inserted into and removed from the root canal. In addition, the drug should be...