Sharif Digital Repository

Physicians use charts that are prepared by experiments on animals or humans to prescribe drug dosage for patients. This method requires much more time by the Ministry of Health to approve new drugs to be used in health-care centers. Furthermore،we have no sight on how a specific drug is going to be diffuse in our body. In order to predict the distribution of a drug or any minerals in the kidney we need to model it. The first step would be modeling the important species that influence the urine concentrating mechanism. Due to the complications in modeling that mechanism especially in the inner medulla zone، we hadn’t solid information regarding that area. It is about half a century that... 

Sulfur containing compounds are known as the most applicable group of organic compounds. Due to their medicinal and biological applications, dithiocarbamates are the most considerable among the many sulfur containing compounds. There are many procedures reported to synthesize these compounds as synthetic intermediates instead of thiophosgen and isothiocyanates. The reaction of amine and carbon disulfide is reported as the best and least hazardous way to synthesize this functional group. In this project heterocyclic compounds such as thiazoles, thiazolidine-2-thione, and 2-(alkylthio)thiazol-4(5H)-one derivatives were synthesized from the reaction of prepared dithiocarbamates with in situ... 

Nowadays Lab-on-a-chip systems are being widely used in medical applications, especially in analyzing minute volumes of blood for diagnosis and treatment of some crucial diaseses like diabetic. A Lab-on-a-chip is comprised of a variety of components such as micromixer, microdispenser, detection and separation units and so on. In this thesis, however, we have analyzed and numerically simulated a microdispenser which is electrokinetically driven. In other words, electrical potentials are applied to electrodes in order to conduct two fluids within a cross microchannel, and distribution of a sample fluid takes place due to appropriately applied potentials. In order to analyze and simulate the... 

Various application of polyethylene material in different industries caused to modern techniques for controlling and measuring specifications of micro-particle suspension. Many industries try to increase stability of suspensions in front of their phase separation.
Because of the consequences of suspension homogeneity, at first, we measured this property. Then, the stability was tested by three different methods. In the first method, the transmitted laser light was measured to assay the suspensions stability. In the second, number of sediments of particles was counted. Sedimentation velocity of particles was measured directly by using a horizontal microscope as the third method. The... 

Polymerase chain reaction, abbreviated as PCR, is a method of amplifying the number of copies of a desired DNA sequence through special protocols. The rapid advance of microfluidic devices and the emerging concept of digital microfluidics has resulted into the development of digital droplet PCR (ddPCR) systems with their significant uses in the detection of rare mutations, cancer diagnosis, and surveillance. In this study, an integrated ddPCR microfluidic chip alongside its thermoelectric thermal cycler and optical analysis systems have been designed, fabricated and their performance has been tested and evaluated. It was shown that the effect of master mold’s surface quality, the material of... 

In this work, a new methodology for modeling the whole lung using porous media is presented. Dealing with the details of the proposed method establishes the need for some tools. Proposed method combines data extraction from lung images to identify large airways, porosity and porous region boundaries. Combining some sequential images, change in properties with time could be obtained. To obtain behavior of this porous media with respect to flow, a method based on the classification of bifurcations and gas exchange areas and pore scale modeling of these classes is proposed. All these require a specifically designed numerical tool. Development of this tool is the subject of the next parts of... 

Dialysis which is an imperfect but most common treatment option for renal failure is divided into two main types:"peritoneal dialysis" and "hemodialysis". Peritoneal dialysis uses a fluid that is placed into the patient's stomach cavity through a special plastic tube to remove excess waste products and fluid from the body.Hemodialysis uses a special type of filter to remove excess waste products and water from the body and is divided to two groups :Clinical and Home.During hemodialysis, blood passes from the patient's body through a filter in the dialysis machine. In this Study first the basic aspect of renal failure and principle of dialysis process are described.Then information about... 

Deep reactive ion etching is one of the most used techniques for manufacturing micro-structures. The most popular silicon DRIE technique is Bosch process. Ability to manufacture high aspect ratio features made Bosch process the main technique for developing micro-electromechanical devices. Dry etching is a combination of physical and chemical processes. The chemical processes play a very important role due to their speed of material removing and also due to their high selectivity. Also chemical processes are responsible for development of passive resist layer on the surface. On the other hand, if not controlled properly it can reduce anisotropy, resulting in a low quality etch. In this... 

The present thesis aims at investigating the dynamic interaction of slosh and aeroelasticity in the fuel contained aero vehicles. The main approach in this research is to develop reduced order models for description of the coupled system. In this regard, boundary element method is used to develop slosh dynamic model. Axisymmetric boundary element method with non-symmetric boundary conditions is used to develop slosh dynamic model for axisymmetric containers. Zoning method is used to develop slosh dynamic model for the multi-baffled tanks and based on it, slosh equivalent mechanical model is developed for multi-baffled tanks. Finite element method along with modal technique is used to develop... 

In recent years, the area of research on micro flying robots has been developed due to the development in micro manufacturing technologies. Due to extra advantages of these flying robots, they are implemented in military and civilian missions such as identifying, espionage, aerial relays, traffic surveillance, rescue, aid, etc. Ability to fly in specified areas, without human injuries, low manufacturing and energy costs, easy and fast implementation, Easy Maintenance, etc, which are some advantages of these robots. We can control these robots manually by remote controllers (RC) or by Auto guidance systems. On the other hand, these robots are used in research laboratories for testing new... 

Range Profile (RP) is known as one of the most important tools for radar target recognition. The main problem with range profile for radar target recognition is its sensitivity to aspect angle. To overcome this problem, range profiles are assumed to have the same statistical characteristics in small frames of aspect angles or context dependent models such as HMM may be used. All methods presented, seems to have some shortcomings to offer a model based on physical circumstances of target maneuver. For example in such models, consecutive samples of RPs in an aspect frame are assumed to be statistically independent with the same distribution (IID). Here we propose dynamic system (DS) for... 

There are numerous ways available to achieve low temperatures that cryocoolers might be among the most important of them. In the meantime, the pulse tube refrigerator has a special place due to its simple geometry and not be using any moving parts. This simple property make the pulse tube refrigerator one of the most popular methods to achieve low temperatures. Nowadays, a pulse tube refrigerator is used for cooling in the range of 4 to 123 Kelvin in two form of one-stage and two-stage and up to an approximate power of 1 KW. Today, due to the temperature and the amount of power required for cooling, as well as the time it takes to reach that temperature, this chiller is used in medical,... 

According to studies, cancer is the second leading cause of death in the world and millions of people die from this disease every year. Early diagnosis is one of the most important factors in controlling and treating the disease. The ability of circulating tumor cells to diagnose and monitor the disease has led many researchers to focus on studying and researching these cells in recent years. However, due to the fact that the concentration of this type of cells in the blood is very low, their isolation is associated with challenges. Various methods isolate CTCs based on physical, biological and other differences in characteristics. In this study, we investigate performance of a microfluidic... 

During the last few years, the study of urban environment structures is considered as a research field of interest in remote sensing. In satellite observations of the earth's surface, continuous imaging in terms of time and space has caused the remote sensing technique to be proposed as a useful and efficient tool for the analysis of urban areas. Obtaining quantitative spatial information from the urban environment in fields such as determining the height of buildings plays an essential role in urban planning, monitoring damage to buildings, establishing communication bases and digital cities. During the last two decades, the use of Tomosar approach in order to reconstruct the structures of... 

A Lab-On-A-Chip is a micro-scale system whic h utilizes some micro-scale components in order to implement detection tests on samples. One of the most important components of a lab-on-a-chip device is the micro-mixer, which is responsible for appropriately mixing of samples in a short period of time. The biggest problem relevant to mixing in micro scales is that since as the viscous forces are dominant in micro scale and dimensions are small, it is impractical to mix fluids via turbulence, and consequently mixing process is performed by diffusion mechanism. Two major strategies are being used in order to improve the mixing performance and two groups of micro-mixers, passive and active types,... 

The mathematical analysis of the kidney has always been considered due to its complex performance. It’s about two decades that mathematicians work on the mathematical modeling of this tissue. Since Glomerular filtration of blood in the kidney has been regarded by physiologists for many years, they can access only to the qualitative data. Mathematicians can solve this problem by numerical modeling. In this research, an engineering model is presented for the analysis of this capillary network by investigating in the different scientific fields such as, physiology, medicine, computer science and mathematics. There are two major renal autoregulatory mechanisms, the myogenic response and the... 

In this thesis we consider the effect of random locations of users in the capacity analysis of SIR-based power control systems and comparison to the strength-based systems, for the first time. Unlike previous works we do not consider a simple deterministic uniform model for the analysis. We provide simulations and analytical solutions for calculating the interference statistics, based on which, we not only calculate the interference statistics, but also study the effect of locating a user in every location in the network coverage area and its share in the interference. We also calculate each cell’s share in every statistics of the interference. In this thesis, based on the common assumption... 

In synthetic aperture radar (SAR) satellites, the nadir echo is defined as the backscattered signal from the point directly below the satellite on the earth surface. If the timing of the radar is such that the nadir echo arrives at the receiver while the receiver is turned on for receiving the desired signal, it could damage the receiver or disrupt the resulting SAR image, unless it is suppressed enough by proper design of antenna radiation pattern. In current SAR satellites, ”avoiding” this phenomenon is associated with two problems: 1) limiting the swath width, 2) imposing stringent restrictions on the selection of pulse repeatition frequency (PRF). Therefore, ”suppressing” the nadir echo,... 

Localization of radio sources has various applications in civil and military communications. Some of important localization methods consist of Angle of Arrival (AoA) estimation of the illuminated signals from the interested sources. Between various Direction Finding (DF) methods, subspace based methods are of special importance, because of their high resolution and accuracy. And from beginning of invention, because of new challenges, have been focus of numerous researches. In this thesis, first we explain the most important subspace based DF methods called MUSIC and root-MUSIC. Then a novel modification for root-MUSIC is introduced. In our new method the computational complexity of...