Sharif Digital Repository

Cellular internalization of inorganic, lipidic and polymeric nanoparticles is of great significance in the quest to develop effective formulations for the treatment of high morbidity rate diseases. Understanding nanoparticle–cell interactions plays a key role in therapeutic interventions, and it continues to be a topic of great interest to both chemists and biologists. The mechanistic evaluation of cellular uptake is quite complex and is continuously being aided by the design of nanocarriers with desired physico-chemical properties. The progress in biomedicine, including enhancing the rate of uptake by the cells, is being made through the development of structure–property relationships in... 

Background: Human papillomavirus (HPV)-associated malignancy remain a main cause of cancer in men and women. Cancer immunotherapy has represented great potential as a new promising cancer therapeutic approach. Here, we report Mesenchymal stem cells (MSCs) as a carrier for the delivery of oncolytic Newcastle disease virus (NDV) for the treatment of HPV-associated tumor. Methods: For this purpose, MSCs obtained from the bone marrow of C57BL mice, then cultured and characterized subsequently by the flow cytometry analysis for the presence of cell surface markers. In this study, we sought out to determine the impacts of MSCs loaded with oncolytic NDV on splenic T cell and cytokine immune... 

The effect of temperature, pressure and bonding time on microstructure of temperature gradient transient liquid phase (TGTLP) diffusion bonded Al7075 alloy using liquid gallium interlayer was investigated. The selected bonding method relies on using the minimum amount of liquid gallium on faying surfaces, using a very fast heating rate to reach the joining temperature and imposing a temperature gradient across the bond region. The microstructure of the diffusion bonded joints was evaluated by light optical microscopy, scanning electron microscopy and energy dispersive spectroscopy (EDS). Results show that by increasing the temperature, pressure and time of joining, a more uniform... 

In this paper, we study the discriminative modeling of Spoken Language Understanding (SLU) using Conditional Random Fields (CRF) and Statistical Machine Translation (SMT) alignment models. Previous discriminative approaches to SLU have been dependent on n-gram features. Other previous works have used SMT alignment models to predict the output labels. We have used SMT alignment models to align the abstract labels and trained CRF to predict the labels. We show that the state transition features improve the performance. Furthermore, we have compared the proposed method with two baseline approaches; Hidden Vector States (HVS) and baseline-CRF. The results show that for the F-measure the proposed... 

Design of an Ultra-Wideband 3-dB quadrature (90°) Hybrid using ADS and HFSS softwares plus Measurement report are presented. Simultaneous Use of these two softwares lead to fast and accurate design procedure. The coupler is realized in broadside stripline and with the connection of coupled regions in tandem structure. The measured data agrees well with the expected values from simulations, and shows a good ultra wide bandwidth response over the frequency range of 1-10 GHz. Measurements showed an amplitude unbalance of ±1.5 dB, a phase unbalance of 90°±7° , and an isolation and a return loss characteristics of more than 14 dB over the frequency of 1 to 10 GHz  

Determining an object location in a specific region is an important task in many machine vision applications. Different parameters affect the accuracy of the localization process. The quantization process in charge-coupled device of a camera is one of the sources of error that causes estimation rather than identifying the exact position of the observed object. A cluster of points, in the field of view of a camera are mapped into a pixel. These points form an uncertainty region. In this paper, we present a geometrical model to analyze the volume of this uncertainty region as a criterion for object localization error. The proposed approach models the field of view of each pixel as an oblique... 

In this paper, a bi-objective multi-products economic production quantity (EPQ) model is developed, in which the number of orders is limited and imperfect items that are re-workable are produced. The objectives of the problem are minimization of the total inventory costs as well as minimizing the required warehouse space. The model is shown to be of a bi-objective nonlinear programming type, and in order to solve it two meta-heuristic algorithms namely, the non-dominated sorting genetic algorithm (NSGA-II) and multi-objective particle swarm optimization (MOPSO) algorithm, are proposed. To verify the solution obtained and to evaluate the performance of proposed algorithms, two-sample t-tests... 

This paper proposes a Low Cost circuit level Fault Detection technique called LCFD for a one-bit Full Adder (FA) as the basic element of adder circuits. To measure the fault detection coverage of the proposed technique, we conduct an exhaustive circuit level fault injection experiment on all susceptible nodes of a FA. Experimental results show that the LCDF technique can detect about 83% of injected faults while having only about 40% area and 22% power consumption overheads. In the LCDF technique, the fault detection latency does not affect the latency of the FA, since the error detection is done in parallel with the addition  

The economic production quantity (EPQ) model is often used in manufacturing environments to assist firms in determining the optimal production lot size that minimizes the overall production-inventory costs. While there are some unrealistic assumptions in the EPQ model that limit its real-world applications, in this research, some of these assumptions such as (1) infinite availability of warehouse space, (2) all of the produced items being perfect, and (3) the existence of one product type are relaxed. In other words, we develop a multi-product EPQ model in which there are some imperfect items of different product types being produced such that reworks are allowed and that there is a... 

The formation of biomimetic bone-like apatite layers throughout the biopolymer-based hydrogel scaffold is an attractive approach in bone tissue engineering. Here, the starch scaffold was prepared using a combination of particulate leaching and freeze-drying techniques. The fabricated structures were then modified by citric acid to investigate the formation of bone-like apatite layer on the porous citrate-based scaffold after soaking in simulated body fluid (SBF). The Fourier Transform Infrared (FTIR) spectra and X-ray diffraction (XRD) patterns revealed that the B-type carbonated apatite has successfully deposited on the scaffold after immersing in SBF for 28 days. Indeed, high chemical... 

In this work, the possibility of capacity enhancement in the South Pars Gas Complex of Iran has been studied. Mass balance is studied and data validation and reconciliation have been carried out in 5th refinery of South Pars Gas Complex in order to achieve the reliable data of the plant. Then the possibility of capacity increase has been studied, taking into account the important parameters such as alteration of the plant pressure profile. Calculation of the key parameters for different equipment at higher feed rate, specified the unit of operations which may have trouble during the capacity enhancement. The performance of export gas compressors, dehydration unit and High-Integrity Pressure... 

In this study, corrosion behaviour of porous NiTi modified by plasma sprayed alumina coating has been investigated. Scanning electron microscopy and X-ray diffraction techniques were applied for the morphology and microstructure characterisation, while linear sweep voltammetry and electrochemical impedance spectroscopy were used for investigation of corrosion behaviour of coated and uncoated NiTi specimens. Induced couple plasma was conducted to measure ion release of the specimens in simulated body fluid at 37°C. The plasma sprayed Al2O3 coating on the porous NiTi improved the surface characteristics for biomedical applications. The alumina coating significantly hampered Ni ion release from... 

An explicit hybrid stabilization method is utilized together with a reduced order integration scheme to stabilize spurious zero energy modes from the sub-integrated degenerated shell element. This stabilization is achieved after employing appropriate contravariant higher order stress modes. The relevant finite element formulation of the piezolaminated nine-nodded shell element is then derived to analyze smart structures behaviors. To show the capabilities of the presented formulation, it has been implemented in a finite element code. The developed code is used to analyze some typical problems. The results are compared with those obtained from other schemes in the literature and experiments  

Geothermal energy is a type of renewable energy with high availability and independence from climatic and atmospheric conditions. It has been shown that geothermal energy is technically, economically and environmentally more suitable for hydrogen production than other renewable sources. Hydrogen has wide applications in many fields including cooling, oil, gas, petrochemical, nuclear, and energy industries. Afghanistan has significant potential in geothermal power generation and also several hydrogen-consuming industries that provide opportunities for geothermal-based hydrogen production. This study attempted to find suitable locations for the construction of geothermal power plant for... 

Optical tweezers are proven and indispensable micro-manipulation tools. It is very common to use an immersion-assisted high NA objective for optical trapping of micrometer-sized beads. However, such objectives suffer from low working depth range. Here we show, both by theory and experiment, that a dry objective can be utilized for optimal trapping of even sub-micrometer objects. For the first time, to the best of our knowledge, we were able to stably trap polystyrene beads with radii of 270 and 175 nm in 3D using an objective with numerical aperture of 0.9. © 2022 Optica Publishing Group  

This paper presents a numerical simulation approach to investigate the water effect as an auxiliary fluid in direct contact with various phase change materials (PCMs). The technique is defined as a hybrid method due to the using of an external intermediary for melting process improvement. Oleic acid (OA), coconut oil (CO), hexadecane, and heptadecane are selected as PCMs due to immiscibility in water and differences in density, melting point, and enthalpy of fusion. An auxiliary fluid is embedded above PCM in an enclosure subjected to sinusoidal wall temperature for melting rate increase through density differences improving heat transfer rate due to materials displacement during process.... 

This study investigates the performance of geogrid-reinforced unbound pavement layer. In this study, geogrid was used in various layouts and numbers using three different gradation of granular materials. Light weight deflectometer (LWD) device is known as a useful tool to evaluate the stiffness of unbound pavement layers. In this study, the LWD was utilized to experimentally investigate factors affecting the performance of geogrid reinforcement, including the number of geogrids, geogrid layout, and the gradation of unbound layer. There are several parameters which affect the LWD test results including the hammer weight, the falling height, and the surface stress. The effect of these... 

This study investigates the performance of geogrid-reinforced unbound pavement layer. In this study, geogrid was used in various layouts and numbers using three different gradation of granular materials. Light weight deflectometer (LWD) device is known as a useful tool to evaluate the stiffness of unbound pavement layers. In this study, the LWD was utilized to experimentally investigate factors affecting the performance of geogrid reinforcement, including the number of geogrids, geogrid layout, and the gradation of unbound layer. There are several parameters which affect the LWD test results including the hammer weight, the falling height, and the surface stress. The effect of these... 

In this paper, a comprehensive analytical study is performed to assess the lycopodium-diesel dual-fuel combustion system in counter-flow premixed configuration. The system is modeled as multiple zones that are coupled together via proper boundary and jump conditions on interfaces. According to the respective reaction and transport phenomena in these zones, conservation equations of mass and energy are derived, non-dimensionalized, and solved by Matlab and Mathematica in an analytical way. The porosity of lycopodium particles and the thermal radiation from the reaction zone and the post-flame zones into the preheating zone are considered, in order to improve the realism and accuracy of the...