Sharif Digital Repository

DNA methylation in one of the most important epigenetic variations, which causes significant variations in gene expressions of mammalians. Our current knowledge about DNA methylation is based on measurments from samples of bulk data which cause ambiguity in intracellular differences and analysis of rare cell samples. For this reason, the ability to measure DNA methylation in single-cells has the potential to play an important role in understanding many biological processes including embryonic developement, disease progression including cancer, aging, chromosome instability, X chromosome inactivation, cell differentiation and genes regulation. Recent technological advances have enabled... 

Minimally invasive surgery is highly valued mainly due to the reduction of the patient’s recovery period. Catheters are among the most important tools in minimally invasive surgeries. Catheter is a flexible tool that has the ability to pass through difficult paths. In common localization methods, fluoroscopy is used to determine the position of the catheter’s tip. One main disadvantage of this method is that it is very dangerous for therapists who are exposed to X-ray radiation for long periods of time. A magnetic catheter is created by adding a magnet to the end of the catheter. The possibility of guiding magnetic catheter by an external magnetic field, controlling the applied force and... 

The human leukocyte antigen protein, commonly known as HLA, has the ability to present small protein fragments called peptides on the surface of cells, whether they originate from within the cell or externally. The binding of these peptides to HLA receptors is a crucial step that triggers an immune response. By estimating the affinity between peptides and HLA class I, we can identify novel antigens that have the potential to be targeted by cancer therapeutic vaccines. Computational methods that predict the binding affinity between peptides and HLA receptors have the potential to expedite the design process of cancer vaccines. Currently, most computational methods exclusively rely on... 

This paper presents a new arrangement of Tuned Mass Dampers (TMDs) for response control of torsionally coupled 3-D building systems under bi-directional seismic inputs. In buildings with symmetric plan, two dampers, optimally designed, can be effectively used along each of the principal directions of the structural models to reduce their lateral displacement. The aim of this study is to explore the application of a torsional TMD to suppress the torsional response of the structures. The so-called Torsional TMD is consisted of two masses that are connected to each other by means of a rigid link. The pair of masses can rotate around the center point of the rigid link which is located on the... 

The main purpose of this project is to propose a control method for medical robots (such as rehabilitation and surgical robots), such that they can be moved conveniently by the users’s hand while he senses a controllable resistance. For that purpose, a Model Reference Adaptive Impedance Control method is developed for controlling the robot end-effector impedance in Cartesian coordinates. The proposed nonlinear controller and the desired impedance model are presented in Cartesian coordinates of the robot end-effector which is sensible for the human user. The adaptation law is derived and a corresponding Lyapunov stability is provided to prove the asymptotic tracking of the impedance model. By... 

Dye-sensitized solar cells (DSCs) are third generation of solar cells, which composed of a porous layer of wide band gap semiconductor such as TiO2, covered with a molecular dye that absorbs sunlight, and a counter electrode contacted by a liquid redox electrolyte. Photovoltaic performance is the collective measure of light harvesting, charge separation and charge collection efficiencies. Light harvesting has a significant role in improvement of photovoltaic performance. Molecular engineering of dyes to improve absorption spectrum or to have a broad absorption spectrum,andlight scattering layes are approaches for this porpuse. This research is focused on photon management in DSCs using... 

In this thesis, the impact of both time offsets (TOs) and carrier frequency offsets (CFOs) on the average output signal-to-interference-plus-noise ratio (SINR) of OFDM systems is investigated with a novel and simple approach. First, TOs are partitioned into five cases based on how they occur. Then the mathematical models for different cases are derived. Considering CFOs and benefiting from the obtained models, closed-form expression for the SINR in each case is derived. It is proved that, SINR is independent of the observed subcarrier for the given TO and CFO. Besides, it is shown that the performance of the affected system deteriorates rapidly as the number of subcarriers increases. It is...