Sharif Digital Repository

The aim of this study is the fabrication of 3D porous PCL scaffolds contain core-shell fibers for cartilage tissue engineering. The novel fabrication method is co-axial wet electrospinning simultaneously. These tablets like scaffolds have superior porosity and pore sizes for cell culturing and cell-cell interaction as they have good mechanical properties for cartilage tissue engineering in comparison to 2D electrospun scaffolds. The structure of these 3D scaffolds is mimicking the ECM of cartilage. This study presents the coaxial electrospinning of PCL nanofibers encapsulated with bovine serum albumin and platelet rich plasma for demonstration of controlled release and bioactivity retention,... 

Due to largre number of patients treated by dialysis and its significant increasing progress, dialysis efficiency and patients' life quality are of great interest.Dialyzer, the dialysis beating heart, has the role of cleaning blood by removing toxic solutes and balancing volume of bood's water through hollow fiber membranes. In this thesis, firstly we tried to focus on performance characteristics of dialyzer by studying effective parameters influencing dialyzer efficiency and ultimately we set two important performance characteristics, ultrafiltration coefficient and solute clearance, as our goal parameters for evaluating dialyzer's yield. To this purpose, we designed an experimental set... 

Osteoarthritis has always been one of the most common diseases in middle age because it causes severe pain and inflammation in the joints of the body. Cartilage tissue does not have the ability to repair itself. For this reason, fabricating and designing the most efficient, least-expensive, and most convenient methods for the treatment of cartilage defects is always an important issue. Today, there are surgical and injectable methods to relieve pain and initiate the body's natural healing response. But due to the many disadvantages and limitations of these methods, tissue engineering science has turned to modifying these methods or providing new methods. One of these methods is the use of... 

This project investigates the simulation of osteochondral defect repair using cell therapy. The osteochondral defect is a common defect among people, where accident, age, and osteoporosis are the main causes of this defect. There are many treatment methods in clinics, which include the using bone allografts, drug treatments, and cell therapy. Cell therapy has been used in this project. For this purpose, firstly, the mathematical equations of the system are written and then the system is simulated using Python. In these equations, ten variables including chondrocyte cells, chondrocyte hypertrophy, osteoblast, different production matrices, and nutrients are used, which are written... 

Reverse osmosis membrane one of the common methods used for water desalination, today membrane, thin film composite(TFC) include three layers, top the these layers named selection layer, this poly amid layer contacted with feed water, sensitivity to chlorine in polyamide layer lead to high membrane chlorine sensitive. Difference methods used for enhance the chlorine resistance in polyamide membrane that categorized in three general categories, covering and protection of sensitive areas method has best results in comparison to other methods. In this research protection method choose and used, material that used, sanitized by result from surface analysis of commercial membrane manufactured in... 

Today cancer is one of the leading causes of death worldwide. It is caused by some cells that they gather together in part of the body and they have an abnormal and very high proliferation rate. Investigations on tumors have shown that when tumor volume increases, oxygen concentration in some regions of tumors decreases and this hypoxic condition leads to some cancer hallmarks, e.g. angiogenesis, deregulation of apoptosis, and shift in cell energy sources. So treatment strategies that can increase tissue oxygenation are good choices for cancers. Hyperbaric oxygen therapy (HBOT) which is used to treat diabetic ulcers and carbon monoxide poisoning, have been used experimentally for cancer and... 

The oxidation-reduction (redox) responsive micelle system is based on a diselenide-containing triblock copolymer, poly(ε-caprolactone)-bis(diselenide-methoxy poly(ethylene glycol)/poly(ethylene glycol)-folate) [PCL-(SeSe-mPEG/PEG-FA)2]. Resulting in the development of tumor-targeted delivery for hydrophobic anticancer drugs. The diselenide bond, as redox-sensitive linkage, was designed, so it is located at the hydrophilic/hydrophobic hinge to allow complete micelles collapse and efficient drug release, in redox environments. The amphiphilic block copolymers self-assembled into micelles at concentrations above the critical micelle concentration (CMC) in an aqueous environment. Dynamic light...